越南茶荣省一般人群中成年人潜伏性结核感染的流行率。

Prevalence of latent tuberculous infection among adults in the general population of Ca Mau, Viet Nam.

机构信息

Woolcock Institute of Medical Research, Hanoi, Viet Nam, South Western Sydney Clinical School, University of New South Wales, Sydney, University of Sydney, Sydney, New South Wales, Australia.

National Lung Hospital, Hanoi, National TB Control Programme, Hanoi, Viet Nam.

出版信息

Int J Tuberc Lung Dis. 2018 Mar 1;22(3):246-251. doi: 10.5588/ijtld.17.0550.

DOI:10.5588/ijtld.17.0550

PMID:29471900

Abstract

SETTING

The study was conducted in a randomly selected sample of persons aged 15 years living in Ca Mau Province, southern Viet Nam.

OBJECTIVE

To estimate the prevalence of latent tuberculous infection (LTBI) in the general adult population of this province of Viet Nam. The secondary objective was to examine age and sex differences in prevalence.

DESIGN

A cross-sectional survey was conducted in a cluster-random sample of the population. Clusters were subcommunes. The presence of LTBI was assessed using the QuantiFERON®-TB Gold In-Tube test system.

RESULTS

QuantiFERON tests were performed among 1319 persons aged 15 years (77.7% of those selected). The overall prevalence of positive tests was 36.8% (95%CI 33.4-40.3). The prevalence of a positive test was lower in females than in males (31.0% vs. 44.7%, OR 0.57, 95%CI 0.45-0.72, P < 0.0001). The prevalence of positive tests increased with increasing age quintile (P < 0.0001).

CONCLUSION

More than one third of the general adult population in a province in southern Viet Nam have evidence of LTBI. Although LTBI prevalence is higher in males, the sex difference is not as great as that for TB notification rates.

摘要

背景

本研究在越南南部茶荣省随机选择的 15 岁及以上人群中进行。

目的

估计越南茶荣省普通成年人群中潜伏性结核感染（LTBI）的流行率。次要目标是检验年龄和性别差异。

设计

采用整群随机抽样的方法对人群进行横断面调查。群为次级行政区。采用 QuantiFERON®-TB Gold In-Tube 检测系统评估 LTBI 的存在。

结果

对 1319 名 15 岁及以上人群（占所选人群的 77.7%）进行了 QuantiFERON 检测。总的阳性检测率为 36.8%（95%CI 33.4-40.3）。女性阳性检测率低于男性（31.0% vs. 44.7%，OR 0.57，95%CI 0.45-0.72，P < 0.0001）。阳性检测率随年龄五分位数的增加而增加（P < 0.0001）。