Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Trends Cell Biol. 2018 May;28(5):368-379. doi: 10.1016/j.tcb.2018.01.006. Epub 2018 Feb 19.
The cell cycle and the circadian clock operate as biological oscillators whose timed functions are tightly regulated. Accumulating evidence illustrates the presence of molecular links between these two oscillators. This mutual interplay utilizes various coupling mechanisms, such as the use of common regulators. The connection between these two cyclic systems has unique interest in the context of aberrant cell proliferation since both of these oscillators are frequently misregulated in cancer cells. Further studies will provide deeper understanding of the detailed molecular connections between the cell cycle and the circadian clock and may also serve as a basis for the design of innovative therapeutic strategies.
细胞周期和生物钟作为生物振荡器运行，其定时功能受到严格调节。越来越多的证据表明这两个振荡器之间存在分子联系。这种相互作用利用了各种耦合机制，例如共同调节剂的使用。在异常细胞增殖的背景下，这两个循环系统之间的联系具有独特的意义，因为这两个振荡器在癌细胞中经常失调。进一步的研究将提供对细胞周期和生物钟之间详细分子联系的更深入理解，也可能为创新治疗策略的设计提供依据。
