Pan Yue, Liu Hao, Chen Jianni, Deng Hongsheng, Yang Chao, Huang Ying, Cai Qi, Huang Weitao, Huang Meiyu, Xiong Shan, Liu Huiting, Huang Linchong, Huang Haiqi, Liang Wenhua, He Jianxing
Department of Thoracic Surgery and Oncology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang Road, Guangzhou, 510120, People's Republic of China.
Guangzhou National Laboratory, No. 9 XingDaoHuanBei Road, Guangzhou International Bio Island, Guangzhou, 510005, Guangdong Province, People's Republic of China.
Biogerontology. 2025 Jul 8;26(4):140. doi: 10.1007/s10522-025-10271-6.
Cell cycle regulation, aging, and metabolism are pivotal biological processes linked to both normal physiology and disease development. Understanding their interplay is crucial for advancing gerontological research and clinical oncology. We analyzed articles and reviews on the cell cycle, aging, and metabolism from 2004 to 2023 using the Web of Science Core Collection. Bibliometric tools, VOSviewer, and CiteSpace, were applied to visualize collaboration networks, geographic distributions, and thematic clusters. Our analysis of 698 papers highlights a growing interest in the intersection of all three of these topics, with a notable publication surge from 2019 to 2022. The United States and China emerged as leading contributors, with significant international collaborations. Research themes evolved around molecular mechanisms, oxidative stress, and the implications for neurodegenerative diseases and cancer. Furthermore, keyword analysis identified five key clusters: neurodegenerative biomarkers, oxidative damage, cell cycle disruptions in cancer, epigenetic links between aging and cancer, and metabolic stress responses. Notably, metabolic shifts associated with aging influence both cellular repair mechanisms and the onset of senescence, indicating a transition from macroscopic changes to microscopic molecular alterations. This bibliometric study systematically maps the scholarly output on the cell cycle, aging, and metabolism, and our findings underscore the importance of molecular and genetic research in understanding the complex interactions and highlight their translational potential in oncology. Future research should explore personalized tumor treatment strategies based on individual cell cycle dynamics and genetic profiling.
细胞周期调控、衰老和代谢是与正常生理和疾病发展相关的关键生物学过程。了解它们之间的相互作用对于推进老年学研究和临床肿瘤学至关重要。我们使用科学网核心合集分析了2004年至2023年期间关于细胞周期、衰老和代谢的文章及综述。应用文献计量工具、VOSviewer和CiteSpace来可视化合作网络、地理分布和主题聚类。我们对698篇论文的分析突出了对这三个主题交叉点的兴趣日益增长，2019年至2022年期间有显著的出版激增。美国和中国成为主要贡献者，并有重要的国际合作。研究主题围绕分子机制、氧化应激以及对神经退行性疾病和癌症的影响展开。此外，关键词分析确定了五个关键聚类：神经退行性生物标志物、氧化损伤、癌症中的细胞周期破坏、衰老与癌症之间的表观遗传联系以及代谢应激反应。值得注意的是，与衰老相关的代谢转变会影响细胞修复机制和衰老的发生，这表明从宏观变化向微观分子改变的转变。这项文献计量研究系统地绘制了关于细胞周期、衰老和代谢的学术产出图谱，我们的研究结果强调了分子和基因研究在理解复杂相互作用中的重要性，并突出了它们在肿瘤学中的转化潜力。未来的研究应探索基于个体细胞周期动态和基因谱分析的个性化肿瘤治疗策略。
