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Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab.

作者信息

Dargaud Yesim, Lienhart Anne, Janbain Maissaa, Le Quellec Sandra, Enjolras Nathalie, Negrier Claude

机构信息

Unite d'Hemostase Clinique, Hopital Cardiologique Louis Pradel, Lyon, France

EA 4609-Hémostase et Cancer, UFR Laennec, Universite Claude Bernard Lyon I, France.

出版信息

Haematologica. 2018 Apr;103(4):e181-e183. doi: 10.3324/haematol.2017.185330. Epub 2018 Feb 22.

DOI:10.3324/haematol.2017.185330
PMID:29472355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5865419/
Abstract
摘要

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本文引用的文献

1
Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?依库珠单抗，一种识别凝血因子 IX 和 X 的双特异性抗体：它与因子 VIII 相比实际情况如何？
Blood. 2017 Dec 7;130(23):2463-2468. doi: 10.1182/blood-2017-08-801662. Epub 2017 Oct 17.
2
Emicizumab Prophylaxis in Hemophilia A with Inhibitors.依库珠单抗预防伴抑制物的血友病 A。
N Engl J Med. 2017 Aug 31;377(9):809-818. doi: 10.1056/NEJMoa1703068. Epub 2017 Jul 10.
3
Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH.关于血友病患者凝血酶生成检测的标准化分析前和分析条件的建议：来自国际血栓与止血学会（ISTH）科学标准化委员会（SSC）的通讯
J Thromb Haemost. 2017 Aug;15(8):1704-1707. doi: 10.1111/jth.13743. Epub 2017 Jun 28.
4
A first-in-human phase 1 study of ACE910, a novel factor VIII-mimetic bispecific antibody, in healthy subjects.一项针对新型VIII因子模拟双特异性抗体ACE910在健康受试者中的首次人体1期研究。
Blood. 2016 Mar 31;127(13):1633-41. doi: 10.1182/blood-2015-06-650226. Epub 2015 Dec 1.
5
Thrombin generation as objective parameter of treatment response in patients with severe haemophilia A and high-titre inhibitors.凝血酶生成可作为重型 A 型血友病伴高滴度抑制物患者治疗反应的客观参数。
Haemophilia. 2014 Jan;20(1):e7-14. doi: 10.1111/hae.12309.
6
Measurement of factor IX activity in plasma-derived and recombinant concentrates: insights from thrombin generation and activation-based assays.血浆源性和重组浓缩物中因子 IX 活性的测量：来自凝血酶生成和基于激活的检测的见解。
J Thromb Haemost. 2014 Jan;12(1):62-70. doi: 10.1111/jth.12452.
7
Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery.前瞻性评估血栓生成试验在接受选择性手术的伴抑制物血友病患者旁路治疗剂量监测中的应用。
Blood. 2010 Dec 16;116(25):5734-7. doi: 10.1182/blood-2010-06-291906. Epub 2010 Sep 1.
8
Insights from factor IX activation studies with chromogenic assays: implications of disparate product results.凝血因子IX显色法激活研究的见解：不同产物结果的影响
Haemophilia. 2010 Jul;16 Suppl 6:9-12. doi: 10.1111/j.1365-2516.2010.02300.x.
9
The effect of tissue factor concentration on calibrated automated thrombography in the presence of inhibitor bypass agents.在存在抑制剂旁路试剂的情况下，组织因子浓度对校准自动血栓形成测定法的影响。
Int J Lab Hematol. 2009 Apr;31(2):189-98. doi: 10.1111/j.1751-553X.2007.01022.x. Epub 2008 Jan 9.
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Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision.一名高滴度抑制物的重度甲型血友病患者的大手术：凝血酶生成试验在治疗决策中的应用
Haemophilia. 2005 Sep;11(5):552-8. doi: 10.1111/j.1365-2516.2005.01141.x.