Nędzi-Góra Małgorzata, Górska Renata, Kostrzewa-Janicka Jolanta, Kowalski Jan
Department of Periodontology and Oral Diseases, Medical University of Warsaw, Poland.
Department of Prosthodontics, Medical University of Warsaw, Poland.
Cent Eur J Immunol. 2017;42(4):342-346. doi: 10.5114/ceji.2017.72824. Epub 2017 Dec 30.
Modern research confirms the role of inflammatory mediators in the pathomechanism of periodontal tissue destruction. The aim of the study was to determine concentrations of MMP-8 and IL-1β in gingival crevicular fluid (GCF) in patients with advanced chronic and aggressive periodontitis. The authors measured the concentrations of the above inflammatory mediators in gingival crevicular fluid of deep pockets (PD ≥ 6 mm) and shallow pockets (PD 4-5 mm) in 33 patients with advanced chronic periodontitis and in 16 patients with aggressive periodontitis. The control group consisted of 16 individuals with healthy periodontium. In all patients levels of MMP-8 and IL-1β in GCF were determined with the ELISA method. The study showed significantly higher concentrations of MMP-8 and IL-1β in GCF of both deep and shallow pockets in patients with periodontitis compared to healthy subjects. No difference in concentrations of the tested mediators was observed with reference to diagnosis of aggressive periodontitis (AP) or chronic periodontitis (CP).
现代研究证实了炎症介质在牙周组织破坏发病机制中的作用。本研究的目的是测定晚期慢性和侵袭性牙周炎患者龈沟液（GCF）中基质金属蛋白酶-8（MMP-8）和白细胞介素-1β（IL-1β）的浓度。作者测量了33例晚期慢性牙周炎患者和16例侵袭性牙周炎患者深牙周袋（牙周袋深度[PD]≥6mm）和浅牙周袋（PD 4-5mm）龈沟液中上述炎症介质的浓度。对照组由16名牙周健康个体组成。采用酶联免疫吸附测定（ELISA）法测定所有患者龈沟液中MMP-8和IL-1β的水平。研究表明，与健康受试者相比，牙周炎患者深牙周袋和浅牙周袋龈沟液中MMP-8和IL-1β的浓度显著更高。在侵袭性牙周炎（AP）或慢性牙周炎（CP）的诊断方面，未观察到所检测介质浓度的差异。
