Alshareef Ahmed, Attia Alaa, Almalki Mohammed, Alsharif Faisal, Melibari Ahmed, Mirdad Bassel, Azab Ehab, Youssef Abdel-Rahman, Dardir Ahmed
Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia.
Faculty of Dentistry, Al-Azhar University, Assiut, Egypt.
Eur J Dent. 2020 Mar;14(2):281-287. doi: 10.1055/s-0040-1709924. Epub 2020 May 21.
The main purpose of this article was to evaluate the effect of probiotics used as an adjunctive to scaling and root planing (SRP) on the periodontal parameters and matrix metalloproteinase-8 (MMP-8) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients.
A total of 25 chronic periodontitis patients who completed the treatment course of 40 subjects, aged 25 to 58 years, participated in this study. They were categorized into two groups: the first group was treated by SRP while the second group was treated by SRP and probiotic lozenges twice a day for 30 days. All patients were evaluated clinically by measuring the plaque index, bleeding index (BI), pocket depth, clinical attachment loss, and immunologically by assaying GCF/MMP-8 at baseline and 30 days after periodontal management.
There was a significant improvement in periodontal parameters after SRP treatment with and without probiotic lozenges in both groups. However, there was a significant decrease in the BI ( = 0.05) in SRP and probiotic lozenges group after 30 days compared with SRP alone. In addition, there was a significant decrease in GCF/MMP-8 levels after 30 days in patients managed by SRP only ( = 0.017) compared with the baseline in both groups, whereas a highly significant decrease in patients treated by SRP and probiotics ( = 0.001).
The current study suggested that the probiotics might have a beneficial effect on clinical and immunological outcomes in the management of chronic periodontitis patients. Further research is needed on a large-scale population and for a long recall time to confirm the response to probiotics as an adjunctive to SRP.
本文的主要目的是评估益生菌作为龈下刮治术和根面平整术（SRP）辅助手段对慢性牙周炎患者牙周参数及龈沟液（GCF）中基质金属蛋白酶-8（MMP-8）水平的影响。
共有25名完成40名受试者治疗疗程的慢性牙周炎患者参与本研究，年龄在25至58岁之间。他们被分为两组：第一组接受SRP治疗，第二组接受SRP治疗并每天服用两次益生菌含片，持续30天。所有患者在基线时以及牙周治疗后30天通过测量菌斑指数、出血指数（BI）、牙周袋深度、临床附着丧失进行临床评估，并通过检测GCF/MMP-8进行免疫学评估。
两组患者在接受含或不含益生菌含片的SRP治疗后，牙周参数均有显著改善。然而，与仅接受SRP治疗相比，30天后SRP联合益生菌含片组的BI显著降低（P = 0.05）。此外，仅接受SRP治疗的患者在30天后GCF/MMP-8水平与基线相比显著降低（P = 0.017），而接受SRP和益生菌治疗的患者GCF/MMP-8水平显著降低（P = 0.001）。
当前研究表明，益生菌可能对慢性牙周炎患者的临床和免疫结局产生有益影响。需要对大规模人群进行进一步研究，并进行长时间随访，以确认益生菌作为SRP辅助手段的效果。
