Nacaroglu Hikmet T, Erdem Semiha Bahceci, Karaman Sait, Yazici Selcuk, Can Demet
Department of Pediatric Allergy and Immunology, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
Department of Paediatrics, Balιkesir University Medical Faculty, Balιkesir, Turkey.
Cent Eur J Immunol. 2017;42(4):358-362. doi: 10.5114/ceji.2017.72808. Epub 2017 Dec 30.
Bronchiectasis (BE) is a parenchymal lung disease evolving as a result of recurrent lung infections and chronic inflammation. Although it has been shown in adult studies that mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) can be used as biomarkers of airway inflammation, knowledge is limited in the paediatric age group. The aim of our study is to investigate the potential of MPV and NLR as biomarkers that may indicate acute exacerbations of non-cystic fibrosis BE in children.
Children with non-cystic fibrosis BE (n = 50), who were followed in the division of Paediatric Pulmonology of our hospital between June 2010 and July 2015, were involved in the present retrospective cross-sectional study. Haemogram values during acute exacerbations and non-exacerbation periods, and a control group were compared.
In children with bronchiectasis, the average leukocyte count (p < 0.001), platelet count (p = 0.018), absolute neutrophil count (p < 0.001), and NLR (p < 0.001) were higher, as expected, when compared with the control group. NLR values, in the period of acute exacerbation were significantly higher than the values of both the non-exacerbation periods (p = 0.02) and the control group (p < 0.001). In contrast, MPV values in the period of acute exacerbation did not exhibit a significant difference from those of non-exacerbation periods (p = 0.530) and the control group (p = 0.103).
It was concluded that leukocyte count, platelet count, absolute neutrophil count, and NLR can be used to show chronic inflammation in BE, but only NLR and absolute neutrophil count can be used as biomarkers to show acute exacerbations.
支气管扩张症（BE）是一种由于反复肺部感染和慢性炎症而演变的实质性肺部疾病。尽管在成人研究中已表明平均血小板体积（MPV）和中性粒细胞与淋巴细胞比值（NLR）可作为气道炎症的生物标志物，但在儿科年龄组中的相关知识有限。我们研究的目的是探讨MPV和NLR作为可能提示儿童非囊性纤维化BE急性加重的生物标志物的潜力。
本回顾性横断面研究纳入了2010年6月至2015年7月在我院儿科肺病科接受随访的非囊性纤维化BE患儿（n = 50）。比较了急性加重期和非加重期的血常规值以及一个对照组。
与对照组相比，支气管扩张症患儿的平均白细胞计数（p < 0.001）、血小板计数（p = 0.018）、绝对中性粒细胞计数（p < 0.001）和NLR（p < 0.001）如预期更高。急性加重期的NLR值显著高于非加重期（p = 0.02）和对照组（p < 0.001）的值。相比之下，急性加重期的MPV值与非加重期（p = 0.530）和对照组（p = 0.103）相比无显著差异。
得出的结论是，白细胞计数、血小板计数、绝对中性粒细胞计数和NLR可用于显示BE中的慢性炎症，但只有NLR和绝对中性粒细胞计数可作为显示急性加重的生物标志物。
