Khanzadeh Shokoufeh, Ghaedi Arshin, Meidani Fatemeh Zari, Rahmati Rahem, Bazrgar Aida, Lucke-Wold Brandon, Khanzadeh Monireh
Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):2191-2204. doi: 10.1007/s12070-023-04306-y. Epub 2023 Dec 22.
Our study aimed to enhance understanding of nasal polyp pathophysiology by reviewing the data for variations of NLR values between patients with nasal polyp and healthy controls. We searched Web of Science, PubMed, ProQuest, and Scopus up to 2 April 2023. The search strategy was not limited to any specific language. Twelve studies were included in our study. Of them, ten studies, involving 898 nasal polyp patients and 590 control patients, were included in the meta-analysis. The NLR levels in nasal polyp patients were statistically greater than in the control group (SMD = 0.56; 95%CI 0.04-1.08, = 0.036). Subgroup analysis based on study design yielded that patients with nasal polyp exhibited significantly higher NLR levels than healthy controls in retrospective studies (SMD = 0.83; 95%CI 0.30-1.35, P = 0.002) but not in prospective studies (SMD = 0.10; 95%CI = -1.03 to 1.23, P = 0.85). Also, we found that the NLR levels in nasal polyp patients were significantly higher than healthy controls in high-quality studies (SMD = 1.00; 95%CI 0.38-1.62, = 0.002) but not in low-quality studies (SMD = 0.11; 95%CI = -0.69 to 0.91, P = 0.79). A total of 312 patients with recurrence and 550 patients without recurrence were included in the study. The combined results revealed that NLR levels in nasal polyp recurrence patients were significantly higher than those of the nasal polyp without recurrence group (SMD = 0.06, 95% CI 0.39-0.81, = 0.000). These results showed the relationship between the NLR in nasal polyps and can help medical doctors to predict the recurrence of the disease in such patients.
我们的研究旨在通过回顾鼻息肉患者与健康对照者之间中性粒细胞与淋巴细胞比值（NLR）值变化的数据，加深对鼻息肉病理生理学的理解。我们检索了截至2023年4月2日的Web of Science、PubMed、ProQuest和Scopus数据库。检索策略不限于任何特定语言。我们的研究纳入了12项研究。其中，10项研究涉及898例鼻息肉患者和590例对照患者，被纳入荟萃分析。鼻息肉患者的NLR水平在统计学上高于对照组（标准化均数差[SMD]=0.56；95%置信区间[CI]0.04 - 1.08，P=0.036）。基于研究设计的亚组分析显示，在回顾性研究中，鼻息肉患者的NLR水平显著高于健康对照者（SMD=0.83；95%CI 0.30 - 1.35，P=0.002），但在前瞻性研究中并非如此（SMD = 0.10；95%CI = -1.03至1.23，P = 0.85）。此外，我们发现，在高质量研究中，鼻息肉患者的NLR水平显著高于健康对照者（SMD=1.00；95%CI 0.38 - 1.62，P=0.002），但在低质量研究中并非如此（SMD = 0.11；95%CI = -0.69至0.91，P = 0.79）。该研究共纳入了312例复发患者和550例未复发患者。综合结果显示，鼻息肉复发患者的NLR水平显著高于未复发的鼻息肉组（SMD=0.06，95%CI 0.39 - 0.81，P=0.000）。这些结果表明了鼻息肉中NLR的关系，有助于医生预测此类患者疾病的复发情况。
