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利妥昔单抗:难治性里德耳甲状腺炎的一种新疗法。

Rituximab: a novel treatment for refractory Riedel's thyroiditis.

作者信息

Hunt Leanne, Harrison Barney, Bull Matthew, Stephenson Tim, Allahabadia Amit

机构信息

Sheffield Teaching Hospitals, Sheffield, UK.

出版信息

Endocrinol Diabetes Metab Case Rep. 2018 Feb 9;2018. doi: 10.1530/EDM-17-0132. eCollection 2018.

Abstract

UNLABELLED

This case report reviews the rare condition of Riedel's thyroiditis via a patient case. The report highlights the difficulties that one may encounter when managing such a case in regards to patient symptoms, side effects of medications and the relapsing nature of the condition. The case report also highlights novel treatment in the treatment of Riedel's thyroiditis, rituximab, how this works and the resolution of symptoms that we have achieved with our patient on this treatment.

LEARNING POINTS

Riedel's thyroiditis is characterised by chronic inflammation, which causes dense fibrosis in the thyroid gland.Riedel's thyroiditis can present with neck pain, dysphagia and dyspnoea with a firm, non-tender mass found on examination.Riedel's thyroiditis is part of the IgG4-related systemic disorders.Rituximab is a monoclonal antibody that works against the protein CD20.

摘要

未标注

本病例报告通过一个患者案例回顾了罕见的里德尔甲状腺炎情况。该报告强调了在处理此类病例时,在患者症状、药物副作用以及病情的复发性方面可能遇到的困难。病例报告还突出了里德尔甲状腺炎治疗中的新疗法——利妥昔单抗,其作用机制以及我们的患者使用该疗法后症状的缓解情况。

学习要点

里德尔甲状腺炎的特征是慢性炎症,会导致甲状腺出现致密纤维化。里德尔甲状腺炎可表现为颈部疼痛、吞咽困难和呼吸困难,检查时可发现一个坚硬、无压痛的肿块。里德尔甲状腺炎是IgG4相关系统性疾病的一部分。利妥昔单抗是一种针对蛋白质CD20的单克隆抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9da/5811771/e92644a9f529/edmcr-2018-170132_g001.jpg

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