解析 FOXO1 在人类肿瘤中的作用。
Deciphering the roles of FOXO1 in human neoplasms.
机构信息
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an, 710069, China.
Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, China.
出版信息
Int J Cancer. 2018 Oct 1;143(7):1560-1568. doi: 10.1002/ijc.31338. Epub 2018 Mar 2.
Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of FOXO1 in neoplasms. This article may serve as a guide for future research and identify FOXO1 as a potent therapeutic target in neoplasms.
肿瘤造成了巨大的负担，导致 2012 年全球估计有 820 万人死亡。FOXO1（叉头框蛋白 O1）是叉头框（FOX）家族的成员，是一种参与多种细胞功能的转录因子。本文集中讨论了 FOXO1 在肿瘤中的抗肿瘤作用的最新研究。本文可为未来的研究提供指导，并将 FOXO1 确定为肿瘤的一个潜在治疗靶点。
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