百里醌的肝脏保护作用概述
An Overview of Hepatoprotective Effects of Thymoquinone.
作者信息
Noorbakhsh Mohammad-Foad, Hayati Farzad, Samarghandian Saeed, Shaterzadeh-Yazdi Hanieh, Farkhondeh Tahereh
机构信息
Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
DVSc Graduate from Department of Surgery and Radiology, School of Veterinary Medicine, Tehran University, Tehran, Iran.
出版信息
Recent Pat Food Nutr Agric. 2018;9(1):14-22. doi: 10.2174/2212798410666180221105503.
BACKGROUND
Liver diseases are globally recognized as major medical problems. Several species of herbal medicine have been investigated for the management of liver-related diseases.
OBJECTIVE
In this context, Thymoquinone (TQ) as the main constituent of Nigella sativa has long been focused for the treatment of liver diseases in recent years. To suppressing liver diseases, it was reported that TQ exhibits hypolipidic effects, which prevented the fatty acid accumulation in the hepatocytes. The other activity of TQ, not only in the management of chronic liver diseases but also regarding the carcinogenesis, is its potent antioxidant effects, which affect several signaling pathways.
RESULT
The effect of TQ on NF-κβ is the hepatoprotective effect of this flavonoid. Recently, a few patents of TQ derivatives for protective effects have been developed. This article also discusses our findings with the patents for this agent.
CONCLUSION
The present review purposed that although the experimental studies indicated the beneficial effects of TQ against liver diseases, more designed clinical trials in human are needed to confirm the safety and efficacy of TQ.
背景
肝脏疾病在全球范围内被公认为主要的医学问题。人们已经对几种草药进行了研究，以用于治疗与肝脏相关的疾病。
目的
在这种背景下，近年来，作为黑种草主要成分的百里醌（TQ）长期以来一直是治疗肝脏疾病的研究重点。据报道，为了抑制肝脏疾病，TQ具有降血脂作用，可防止脂肪酸在肝细胞中积累。TQ的另一项作用，不仅体现在对慢性肝病的治疗上，还体现在致癌作用方面，即其强大的抗氧化作用，可影响多种信号通路。
结果
TQ对NF-κβ的作用是这种类黄酮的肝脏保护作用。最近，已经开发了一些具有保护作用的TQ衍生物专利。本文还讨论了我们关于该药物专利的研究结果。
结论
本综述旨在表明，尽管实验研究表明TQ对肝脏疾病有益，但仍需要更多针对人类的设计良好的临床试验来确认TQ的安全性和有效性。
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