Tania Mousumi, Asad Asaduzzaman, Li Tian, Islam Md Shariful, Islam Shad Bin, Hossen Md Munnaf, Bhuiyan Mizanur Rahman, Khan Md Asaduzzaman
Research Division of Nature Study Society of Bangladesh, Dhaka, Bangladesh.
Division of Molecular Cancer, Red Green Research Center, Dhaka, Bangladesh.
Iran J Basic Med Sci. 2021 Aug;24(8):1014-1022. doi: 10.22038/ijbms.2021.56250.12548.
The recent pandemics caused by coronavirus infections have become major challenges in 21 century human health. Scientists are struggling hard to develop a complete cure for infectious diseases, for example, drugs or vaccines against these deadly infectious diseases. We have searched papers on thymoquinone (TQ) and its effects on different infectious diseases in databases like Pubmed, Web of Science, Scopus, and Google Scholar, and reviewed them in this study. To date research suggests that natural products may become a potential therapeutic option for their prodigious anti-viral or anti-microbial effects on infectious diseases. TQ, a natural phytochemical from black seeds, is known for its health-beneficial activities against several diseases, including infections. It is evident from different and studies that TQ is effective against tuberculosis, influenza, dengue, Ebola, Zika, hepatitis, malaria, HIV, and even recent pandemics caused by severe acute respiratory syndrome of coronaviruses (SARS-CoV and SARS-CoV-2). In these cases, the molecular mechanism of TQ is partly clear but mostly obscure. In this review article, we have discussed the role of TQ against different infectious diseases, including COVID-19, and also critically reviewed the future use of TQ use to fight against infectious diseases.
近期由冠状病毒感染引发的大流行已成为21世纪人类健康面临的重大挑战。科学家们正在努力研发针对传染病的彻底治愈方法，例如针对这些致命传染病的药物或疫苗。我们在PubMed、科学网、Scopus和谷歌学术等数据库中搜索了关于百里醌（TQ）及其对不同传染病影响的论文，并在本研究中对其进行了综述。迄今为止的研究表明，天然产物因其对传染病具有巨大的抗病毒或抗菌作用，可能成为一种潜在的治疗选择。TQ是一种来自黑种草籽的天然植物化学物质，以其对包括感染在内的多种疾病的有益健康作用而闻名。从不同的[此处原文缺失相关内容]和[此处原文缺失相关内容]研究中可以明显看出，TQ对结核病、流感、登革热、埃博拉、寨卡、肝炎、疟疾、艾滋病毒，甚至由冠状病毒严重急性呼吸综合征（SARS-CoV和SARS-CoV-2）引发的近期大流行都有效。在这些情况下，TQ的分子机制部分清晰但大多仍不清楚。在这篇综述文章中，我们讨论了TQ在对抗包括COVID-19在内的不同传染病中的作用，并对TQ在抗击传染病方面的未来应用进行了批判性综述。
