Leggett Rich, O'Connell Cailin
Environmental Sciences Division Building 1505, Room 380 Oak Ridge National Laboratory Oak Ridge, Tennessee 37831, United States of America.
J Radiol Prot. 2018 Jun;38(2):564-586. doi: 10.1088/1361-6498/aab1c1. Epub 2018 Feb 23.
This paper reviews biokinetic data for the Group VB elements vanadium, niobium, and tantalum, and presents biokinetic models describing their systemic behaviour. The model for systemic niobium in adults was developed earlier and described in Publication 134 of the International Commission on Radiological Protection. The model for niobium is used as a starting point for the development of models for vanadium and tantalum. Published biokinetic data for vanadium, including comparisons with niobium, indicate that the initial distribution of vanadium is broadly similar to that of niobium but that vanadium is less firmly fixed in most tissues and is excreted more rapidly than niobium. Biokinetic data for tantalum are more limited but suggest that its systemic behaviour closely resembles that of niobium at early times after administration. The model for niobium is proposed for application to tantalum in view of the suggested biological similarities of tantalum and niobium, their generally strong coherence in nature due to similar ionic radii and identical valence states, and the difficulties in developing parameter values directly from available data for tantalum. The proposed model for vanadium relies largely on vanadium-specific information and varies considerably from the model for niobium.
本文回顾了第VB族元素钒、铌和钽的生物动力学数据，并给出了描述它们全身行为的生物动力学模型。成人全身铌的模型是较早建立的，并在国际放射防护委员会第134号出版物中有所描述。铌的模型被用作开发钒和钽模型的起点。已发表的钒生物动力学数据，包括与铌的比较，表明钒的初始分布与铌大致相似，但钒在大多数组织中的固定程度较低，排泄速度比铌快。钽的生物动力学数据较为有限，但表明在给药后的早期，其全身行为与铌非常相似。鉴于钽和铌在生物学上的相似性、由于离子半径相似和价态相同而在性质上通常具有很强的一致性，以及直接从钽的现有数据中得出参数值的困难，建议将铌的模型应用于钽。所提出的钒模型主要依赖于钒的特定信息，与铌的模型有很大差异。
