From the Department of Orthopaedic Surgery, Oakland University William Beaumont School of Medicine, Oakland, MI (Dr. Grant, Dr. Busse, Dr. Park, and Dr. Baker), and the Department of Orthopaedic Surgery, Beaumont Hospital Research Institute, Oakland (Dr. Baker).
J Am Acad Orthop Surg. 2018 Mar 1;26(5):166-174. doi: 10.5435/JAAOS-D-16-00142.
Osteoporosis is one of the costliest conditions managed by orthopaedic surgeons. This condition, which is characterized by decreased bone density and thinning of cortical bone, is strongly influenced by complex signaling in both the hormonal and mechanical environments. Osteoporosis cannot be cured; instead, it can only be managed to decrease patient morbidity. Current pharmacologic treatments are aimed at minimizing bone turnover and have substantial side effects. Therefore, much work remains to find safer and more effective agents to restore bone density. In addition to the high incidence of fracture in elderly patients, many of the traditional fixation constructs used for repair of these fractures are not suitable for use in osteoporotic bone. Increased use of fixed-angle locking plates, intramedullary devices, and bone substitutes has greatly improved outcomes in these patients.
骨质疏松症是骨科医生治疗费用最高的疾病之一。这种疾病的特征是骨密度降低和皮质骨变薄，受激素和机械环境中复杂信号的强烈影响。骨质疏松症无法治愈，只能通过管理来降低患者的发病率。目前的药物治疗旨在最大限度地减少骨转换，并具有显著的副作用。因此，仍有大量工作需要找到更安全、更有效的药物来恢复骨密度。除了老年患者骨折发生率高外，用于修复这些骨折的许多传统固定结构都不适合骨质疏松症患者使用。增加使用角度锁定钢板、髓内装置和骨替代物大大改善了这些患者的预后。
