Locke Saskia, Doonan James, Jones Bryn
Orthopaedics, Glasgow Royal Infirmary, Glasgow, GBR.
Cureus. 2024 Nov 20;16(11):e74065. doi: 10.7759/cureus.74065. eCollection 2024 Nov.
Osteoporosis is a major risk factor for fragility fractures. The British Orthopaedics Association Standards for Trauma and Orthopaedics (BOAST) and Getting it Right First Time (GIRFT) guidelines on fragility fracture management highlight the need to initiate prompt, coordinated multidisciplinary care with a focus on early mobilisation to improve patient outcomes. Medical management of fragility fractures focuses on the prevention of progressive frailty. Advancements in medical therapy include romosozumab, recommended by the National Institute for Health and Care Excellence guidance in patients with imminent fracture risk, which improves overall bone mineral density. Regional nerve blocks are an increasingly common form of perioperative anaesthesia with fewer side effects than opioids and rates of postoperative delirium. Surgical management of osteoporotic fractures poses unique challenges, such as complex fracture patterns and increased risk of implant failure. The surgical approach to fragility fractures has undergone major advancements over the past 20 years, with developments such as polyaxial locking and far cortical locking systems that achieve secondary bone healing, as well as cement augmented screw fixation to provide stable fixation in osteoporotic bone. The development of minimally invasive surgical approaches has led to improved periosteal blood flow around a fracture site, as well as reduced operating time, hospital stay, and time to pain-free weight-bearing. In the future, we are likely to see a focus on minimally invasive surgical techniques for vertebral and pelvic fragility fractures to improve patients' mobility and independence before discharge, subsequently improving quality of life and preventing progressive frailty.
骨质疏松症是脆性骨折的主要危险因素。英国骨科学会创伤与骨科标准(BOAST)以及“一次做对”(GIRFT)脆性骨折管理指南强调,需要启动迅速、协调的多学科护理,重点是早期活动以改善患者预后。脆性骨折的药物治疗侧重于预防渐进性衰弱。医学治疗的进展包括罗莫单抗,英国国家卫生与临床优化研究所指南推荐用于有即将发生骨折风险的患者,它可提高总体骨密度。区域神经阻滞是一种越来越常见的围手术期麻醉方式,其副作用比阿片类药物少,术后谵妄发生率也较低。骨质疏松性骨折的手术治疗带来了独特的挑战,如复杂的骨折模式和植入物失败风险增加。过去20年里,脆性骨折的手术方法取得了重大进展,出现了多轴锁定和远皮质锁定系统等技术,可实现二期骨愈合,还有骨水泥增强螺钉固定,能在骨质疏松性骨中提供稳定固定。微创外科手术方法的发展改善了骨折部位周围的骨膜血流,同时减少了手术时间、住院时间和无痛负重时间。未来,我们可能会看到针对椎体和骨盆脆性骨折的微创外科技术将成为重点,以在出院前改善患者的活动能力和独立性,进而提高生活质量并预防渐进性衰弱。