University of Occupational and Environmental Health School of Medicine, Department of Radiology, Yahatanishi-ku Kitakyushu-shi, Fukuoka, Japan.
University of Occupational and Environmental Health School of Medicine, First Department of Internal Medicine, Yahatanishi-ku Kitakyushu-shi, Fukuoka, Japan.
J Magn Reson Imaging. 2018 Nov;48(5):1237-1246. doi: 10.1002/jmri.25966. Epub 2018 Feb 23.
Systemic lupus erythematosus (SLE) is related to vasculitis, which causes brain infarctions; however, the pathology of large cerebral vessels has not been fully established.
To demonstrate the prevalence of vessel wall lesions (VWLs) in SLE patients using 3D vessel wall imaging and to assess the relationship between VWLs and brain infarctions.
Retrospective.
Sixty SLE patients and 50 healthy subjects (HS).
FIELD STRENGTH/SEQUENCE: Each subject underwent 3T MRI, which included 3D FSE PDWI (CUBE).
For each of the 33 segments of the intracranial artery (internal carotid artery ∼ M3 segment of middle cerebral artery [MCA]), the VWLs were scored as either positive or negative, and the VWL score was calculated as the sum of the segments with VWLs. We also evaluated brain lesions on conventional MRI.
We used logistic regression analyses to determine the clinical (serological test and cardiovascular risk factors) and imaging characteristics associated with infarctions in SLE patients.
For the peripheral vessels such as MCA, VWLs were more common for SLE patients than for HS (43.3% versus 16.7% in M1 segment, 60.4% versus 16.7% in M2 segment, both P < 0.01). There were 21 infarctions in 13 patients (21.7%), and the median VWL score was larger in the patients with infarctions than in those without (13 versus 6, P < 0.01). Multivariate logistic regression analyses revealed a high VWL score ( ≥ 9) to be the only factor independently associated with the presence of infarctions (odds ratio: 10.1, 95% confidence interval: 1.01-101; P < 0.049).
We demonstrated a substantially high prevalence of VWLs among SLE patients, which were associated with brain infarctions.
3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1237-1246.
系统性红斑狼疮（SLE）与血管炎有关，后者可导致脑梗死；然而，大动脉的病理学尚未完全确定。
使用 3D 血管壁成像技术显示 SLE 患者的血管壁病变（VWL）发生率，并评估 VWL 与脑梗死之间的关系。
回顾性研究。
60 例 SLE 患者和 50 例健康对照者（HS）。
磁场强度/序列：每位受试者均接受 3T MRI 检查，包括 3D FSE PDWI（CUBE）。
对颅内动脉（颈内动脉~大脑中动脉 M3 段）的 33 个节段，分别对 VWL 进行阳性或阴性评分，并将 VWL 评分计算为有 VWL 的节段的总和。我们还评估了常规 MRI 上的脑病变。
我们使用逻辑回归分析来确定与 SLE 患者梗死相关的临床（血清学检查和心血管危险因素）和影像学特征。
对于 MCA 等外周血管，SLE 患者的 VWL 比 HS 更常见（M1 段为 43.3%比 16.7%，M2 段为 60.4%比 16.7%，均 P<0.01）。13 例患者中有 21 例出现梗死（21.7%），有梗死的患者 VWL 评分中位数大于无梗死的患者（13 比 6，P<0.01）。多变量逻辑回归分析显示，高 VWL 评分（≥9）是唯一与梗死存在相关的独立因素（比值比：10.1，95%置信区间：1.01-101；P<0.049）。
我们证明了 SLE 患者的 VWL 发生率明显较高，与脑梗死有关。
3 级 技术功效：2 级 JMRI 2018；47：1237-1246.
