Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
J Magn Reson Imaging. 2019 Nov;50(5):1452-1460. doi: 10.1002/jmri.26750. Epub 2019 Apr 17.
Intracranial vessel wall imaging (VWI) at a clinical field strength of 3T has become more widely available. However, how vessel measurements change with age and sex, over an age range spanning a typical lifespan, are needed.
PURPOSE/HYPOTHESIS: To assess for identifiable changes in arterial wall thickness, outer vessel wall diameter, and lumen diameter with age cross-sectionally in healthy controls without cerebrovascular disease risk factors at the spatial resolution afforded by currently recommended 3T VWI approaches.
Prospective.
POPULATION/SUBJECTS: Healthy subjects (n = 82; age = 8-79 years).
FIELD STRENGTH/SEQUENCE: 3T intracranial VWI, angiography, and T -weighted anatomical imaging.
Two readers measured lumen and outer wall diameters of the supraclinoid internal carotid artery (ICA) and distal basilar artery. Wall thickness and intraclass correlation coefficients (ICCs) were calculated.
Separate linear regressions were performed to understand the relationship between wall measurements (lumen diameter, outer vessel wall diameter, and wall thickness) and age, gender, side (left or right); significance: two-sided P < 0.05.
Readers showed excellent agreement for lumen and outer wall diameters (ICC 0.83-094). Linear regression of supraclinoid ICA wall measurements showed a statistically significant increase in wall thickness (P = 0.00051) and outer vessel wall diameter (P = 0.030) with age. ICA lumen and outer vessel wall diameters were statistically greater in males vs. females (lumen diameter 3.69 ± 0.41 vs. 3.54 ± 0.35 mm, P = 0.026; outer wall diameter 5.78 ± 0.52 vs. 5.56 ± 0.44 mm, P = 0.0089) with a trend toward increase in wall thickness (1.05 ± 0.12 vs. 1.01 ± 0.10 mm, P = 0.055). No significant difference was found in basilar artery wall thickness (P = 0.45, P = 0.72), lumen diameter (P = 0.15, P = 0.42), or outer vessel wall diameter (P = 0.34, P = 0.41) with age or gender, respectively.
Intracranial vessel wall measurements were shown to be consistent between readers. At the available spatial resolution of 3T intracranial VWI sequences, supraclinoid ICA vessel wall thickness and outer vessel wall diameter appear to mildly increase with age. There was no detectable change in basilar artery vessel wall characteristics with age.
2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:1452-1460.
在临床 3T 场强下，颅内血管壁成像（VWI）的应用越来越广泛。然而，需要了解在没有脑血管疾病风险因素的情况下，健康对照者的血管壁厚度、外血管壁直径和管腔直径如何随年龄发生变化，跨越典型寿命范围。
目的/假设：评估在目前推荐的 3T VWI 方法所提供的空间分辨率下，健康对照者中无脑血管疾病危险因素的情况下，动脉壁厚度、外血管壁直径和管腔直径是否随年龄发生可识别的变化。
前瞻性。
人群/受试者：健康受试者（n=82；年龄 8-79 岁）。
场强/序列：3T 颅内 VWI、血管造影和 T1 加权解剖成像。
两位读者测量了颈内动脉（ICA）颅外段和基底动脉远端的管腔和外血管壁直径。计算了壁厚度和组内相关系数（ICC）。
分别进行线性回归，以了解壁测量值（管腔直径、外血管壁直径和壁厚度）与年龄、性别、侧别（左或右）之间的关系；显著性：双侧 P<0.05。
读者对管腔和外血管壁直径的测量值显示出极好的一致性（ICC 0.83-0.94）。颈内动脉颅外段壁测量的线性回归显示，壁厚度（P=0.00051）和外血管壁直径（P=0.030）随年龄呈统计学显著增加。男性的 ICA 管腔和外血管壁直径均大于女性（管腔直径 3.69±0.41 与 3.54±0.35mm，P=0.026；外血管壁直径 5.78±0.52 与 5.56±0.44mm，P=0.0089），壁厚度呈增加趋势（1.05±0.12 与 1.01±0.10mm，P=0.055）。基底动脉壁厚度（P=0.45，P=0.72）、管腔直径（P=0.15，P=0.42）或外血管壁直径（P=0.34，P=0.41）均未随年龄或性别而发生统计学显著变化。
颅内血管壁测量值在读者之间具有一致性。在 3T 颅内 VWI 序列的现有空间分辨率下，颈内动脉颅外段血管壁厚度和外血管壁直径似乎随年龄轻度增加。基底动脉血管壁特征随年龄无明显变化。
2 技术功效：3 级 J. Magn. Reson. Imaging 2019；50：1452-1460.
