Wang Xiaowen, Guo Guangping, Liang Xiumin, Zhou Ling, Zheng Jiarui, Li Shaoqin, Luo Hongzhuan, Yang Yuyan, Yang Liyuan, Tan Ting, Yu Jun, Lu Lin
Yunnan Centers for Disease Control and Prevention, Kunming, Yunnan, China; Department of Public Health, Kunming Medical University, Kunming, Yunnan, China.
Yunnan Maternal and Child Health Care hospital, Kunming, Yunnan, China.
Value Health Reg Issues. 2018 May;15:27-33. doi: 10.1016/j.vhri.2017.05.004. Epub 2017 Jul 3.
Health utility (HU) is essential to understanding the effects of HIV infection as a chronic disease. No HU data on pregnant women living with human immunodeficiency virus (HIV) in Yunnan Province are available. This study aims to construct a database on HU and explore factors associated with HU by pregnant women living with HIV/acquired immunodeficiency syndrome (AIDS) who were enrolled in the Prevention of mother-to-child transmission of HIV (PMTCT) programs in Yunnan Province.
A cross-sectional study was conducted in Yunnan Province on pregnant women living with HIV who were selected by convenience sampling. Sociodemographic, HIV-related, social support, and HU data were collected through face-to-face interviews. The European quality of life five-dimensional three-level (EQ-5D-3L) questionnaire and the social support rate scale (SSRS) were applied.
One hundred and one pregnant women (mean age of 30.4 ± 5.1 years) participated in the survey. The mean EQ-5D index score and the EQ visual analogue scale (EQ-VAS) score of participants were 0.77 (95% confidence interval [CI] 0.74-0.79) and 75.77 (95% CI 75.00-80.00), respectively. The effect of social support on HU was maintained significant difference even after adjusting for such factors as education level, household income per year, and HIV disclosure, demonstrating a significant difference within EQ-5D index scores and EQ-VAS scores.
Pregnant women living with HIV/AIDS who were enrolled in PMTCT programs reported the same level of HU as other patients living with HIV/AIDS. Integrating measurements of HU by using the EQ-5D-3L questionnaire could be helpful for economic evaluation of the PMTCT program. This study also suggests a potential benefit of appropriate social support.
健康效用（HU）对于理解作为一种慢性病的HIV感染的影响至关重要。目前尚无关于云南省感染人类免疫缺陷病毒（HIV）的孕妇的HU数据。本研究旨在构建一个HU数据库，并探索参与云南省预防母婴传播HIV（PMTCT）项目的感染HIV/获得性免疫缺陷综合征（AIDS）的孕妇的HU相关因素。
在云南省对通过便利抽样选取的感染HIV的孕妇进行了一项横断面研究。通过面对面访谈收集社会人口学、HIV相关、社会支持和HU数据。应用欧洲生活质量五维度三级（EQ-5D-3L）问卷和社会支持评定量表（SSRS）。
101名孕妇（平均年龄30.4±5.1岁）参与了调查。参与者的平均EQ-5D指数得分和EQ视觉模拟量表（EQ-VAS）得分分别为0.77（95%置信区间[CI]0.74-0.79）和75.77（95%CI 75.00-80.00）。即使在调整了教育水平、家庭年收入和HIV披露等因素后，社会支持对HU的影响仍保持显著差异，在EQ-5D指数得分和EQ-VAS得分方面显示出显著差异。
参与PMTCT项目的感染HIV/AIDS的孕妇报告的HU水平与其他感染HIV/AIDS的患者相同。使用EQ-5D-3L问卷整合HU测量可能有助于对PMTCT项目进行经济评估。本研究还表明了适当社会支持的潜在益处。
