Wang Xiaowen, Guo Guangping, Zhou Ling, Zheng Jiarui, Liang Xiumin, Li Zhanqin, Luo Hongzhuan, Yang Yuyan, Yang Liyuan, Tan Ting, Yu Jun, Lu Lin
Department of Public Health, Kunming Medical University, Yunnan, China.
Yunnan Centers for Disease Control and Prevention, Yunnan, China.
Health Qual Life Outcomes. 2017 Aug 30;15(1):158. doi: 10.1186/s12955-017-0731-8.
This paper investigates the properties and performance of the two generic measures, EQ-5D and SF-12, for Health-Related Quality of Life (HRQoL) assessments of pregnant women living with HIV in Kunming City, Yiliang County, Daguan County, Longchuan County, Tengchong County, Longling County and Fengqing County in Yunnan Province, China.
As part of a screening programme for the prevention of mother-to-child transmission of HIV (PMTCT), a retrospective cross-sectional survey was conducted in the seven Maternal and Infant Health Care centers in Yunnan Province, China, between April and June of 2016. The demographic and HIV infection-related information used in the study was collected through questionnaires designed by the study's staff. HRQoL information was collected using two generic scales: EQ-5D and SF-12.
A total sample of one hundred and one pregnant women with a mean age of 30.4 ± 5.1 years was investigated. Average time elapsed since infection diagnoses was 5.8 ± 3.4 years. Only one infant (1.0%) was HIV positive, and 56 (55.4%) infants were HIV negative. The HIV status of 44 (43.6%) infants was unknown. The relationship between the EQ-5D functional dimensions and the PCS-12 and the relationship between the EQ-5D anxiety/depression dimension and the MCS-12 were stronger. Those whose PCS-12 and MCS-12 scores were at the median or lower were classified as being in worse health, while those over the median were classified as being in better health. Respondents who reported no problem on each of the EQ-5D dimensions was divided according to the median SF-12 component scores. Those who scored at the median or lower than the median were classified as being in worse health, while those higher than the median were classified as being in better health. The VAS scores were also significantly different than the median split of the SF-12 scores for these subjects.
EQ-5D and SF-12 showed a discrimination ability in measuring the HRQoL of pregnant women living with HIV. The construct validity was identified for EQ-5D and SF-12 in the study. The respective constructs of EQ-5D and EQ-VAS may not overlap. Pregnant women living with HIV in the study gave more weight to their mental health when they provided a total health rating in EQ-VAS. EQ-VAS could explain the limitations of the EQ-5D dimension scores with ceiling effects in the survey. The results of our study could help to determine the suitable HRQoL instruments for pregnant women living with HIV and provide evidence for the proper comparison of EQ-5D and SF-12.
本文研究了两种通用测量工具EQ-5D和SF-12在评估中国云南省昆明市、宜良县、大关县、龙川县、腾冲县、龙陵县和凤庆县感染艾滋病毒的孕妇的健康相关生活质量（HRQoL）方面的特性和表现。
作为预防艾滋病毒母婴传播（PMTCT）筛查项目的一部分，2016年4月至6月在中国云南省的七个母婴保健中心进行了一项回顾性横断面调查。研究中使用的人口统计学和艾滋病毒感染相关信息通过研究人员设计的问卷收集。HRQoL信息使用两种通用量表收集：EQ-5D和SF-12。
共调查了101名平均年龄为30.4±5.1岁的孕妇。自感染诊断以来的平均时间为5.8±3.4年。只有一名婴儿（1.0%）艾滋病毒呈阳性，56名（55.4%）婴儿艾滋病毒呈阴性。44名（43.6%）婴儿的艾滋病毒感染状况未知。EQ-5D功能维度与PCS-12之间的关系以及EQ-5D焦虑/抑郁维度与MCS-12之间的关系更强。PCS-12和MCS-12得分处于中位数及以下的人被归类为健康状况较差，而得分高于中位数的人被归类为健康状况较好。在EQ-5D各维度上均报告无问题的受访者根据SF-12分量表得分中位数进行划分。得分处于中位数及以下的人被归类为健康状况较差，而得分高于中位数的人被归类为健康状况较好。这些受试者的VAS得分也与SF-12得分的中位数划分存在显著差异。
EQ-5D和SF-12在测量感染艾滋病毒的孕妇的HRQoL方面显示出区分能力。本研究确定了EQ-5D和SF-12的结构效度。EQ-5D和EQ-VAS各自的结构可能不重叠。本研究中感染艾滋病毒的孕妇在通过EQ-VAS提供总体健康评分时更重视其心理健康。EQ-VAS可以解释调查中EQ-5D维度得分存在天花板效应的局限性。我们的研究结果有助于确定适合感染艾滋病毒孕妇的HRQoL工具，并为EQ-5D和SF-12的合理比较提供证据。
