Setiawan Didik, Dusafitri Arrum, Galistiani Githa Fungie, van Asselt Antoinette D I, Postma Maarten J
Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia.
Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia.
Value Health Reg Issues. 2018 May;15:63-69. doi: 10.1016/j.vhri.2017.07.010. Epub 2017 Sep 3.
Human papillomavirus (HPV)-related cancers are a serious concern in developing countries. Valid estimates of a country-specific health-related quality of life (HRQOL) for patients with HPV-related cancers provide a substantial tool in determining the burden of the disease.
To investigate the HRQOL of patients with HPV-related cancers in Indonesia.
The HRQOL of patients with HPV-related cancers (cervical, uterine, nasopharyngeal, head and neck, and anogenital cancer) was assessed using the EuroQol five-dimensional questionnaire (EQ-5D). Validity and reliability were assessed by means of construct validity and test-retest reliability methods, respectively. Subsequently, the EQ-5D utility index was calculated using the Thailand value set.
The EQ-5D came out as a valid and reliable questionnaire for measuring the HRQOL of patients with HPV-related cancers in Indonesia. From a total of 520 patients diagnosed with HPV-related cancers, 404 patients were excluded because of not fulfilling the inclusion criteria, and so 116 patients finally participated in the study. The mean age of the patients was 47.5 ± 12.03 years. Most of the patients were women (56.0%) and married (97.4%), and less than half of them had finished high school (32.7%). Moreover, the proportions of nasopharyngeal, cervical, head and neck, anogenital, and uterine cancers in the study population were 29.3%, 24.6%, 22.4%, 14.2%, and 9.5%, respectively. The average HRQOL of the patients with HPV-related cancers was 0.69 ± 0.10, with the highest and lowest estimates applying to uterine cancer (0.84 ± 0.29) and head and neck cancer (0.58 ± 0.33), respectively.
The HRQOL of patients with HPV-related cancers was found to be reduced to a certain extent in our study for Indonesia.
人乳头瘤病毒（HPV）相关癌症在发展中国家是一个严重问题。对HPV相关癌症患者特定国家的健康相关生活质量（HRQOL）进行有效评估，为确定该疾病负担提供了一个重要工具。
调查印度尼西亚HPV相关癌症患者的健康相关生活质量。
使用欧洲五维健康量表（EQ-5D）评估HPV相关癌症（宫颈癌、子宫癌、鼻咽癌、头颈癌和肛门生殖器癌）患者的健康相关生活质量。分别通过结构效度和重测信度方法评估效度和信度。随后，使用泰国值集计算EQ-5D效用指数。
EQ-5D是一种有效且可靠的问卷，可用于测量印度尼西亚HPV相关癌症患者的健康相关生活质量。在总共520例被诊断为HPV相关癌症的患者中，404例因不符合纳入标准而被排除，最终116例患者参与研究。患者的平均年龄为47.5±12.03岁。大多数患者为女性（56.0%）且已婚（97.4%），不到一半的患者完成了高中学业（32.7%）。此外，研究人群中鼻咽癌、宫颈癌、头颈癌、肛门生殖器癌和子宫癌的比例分别为29.3%、24.6%、22.4%、14.2%和9.5%。HPV相关癌症患者的平均健康相关生活质量为0.69±0.10，最高和最低估计值分别适用于子宫癌（0.84±0.29）和头颈癌（0.58±0.33）。
在我们针对印度尼西亚的研究中，发现HPV相关癌症患者的健康相关生活质量在一定程度上有所降低。
