Division of Nephrology and Immunology, RWTH University of Aachen, Aachen, Germany.
Kidney Int. 2018 Mar;93(3):542-544. doi: 10.1016/j.kint.2017.10.028.
The diagnosis of IgA nephropathy relies on the histologic demonstration of glomerular mesangial IgA deposits. However, only a very small fraction of IgA, namely, galactose-deficient IgA1, seems to induce the disease. So far, this type of IgA could only be detected using mass spectrometry or lectins, which are relatively difficult to standardize. A novel monoclonal antibody, KM55, specifically recognizing galactose-deficient IgA1, may now change this.
IgA 肾病的诊断依赖于肾小球系膜 IgA 沉积的组织学表现。然而，只有一小部分 IgA，即半乳糖缺乏的 IgA1，似乎会引发这种疾病。到目前为止，这种类型的 IgA 只能使用质谱或凝集素来检测，而这些方法相对较难标准化。一种新型的单克隆抗体 KM55，专门识别半乳糖缺乏的 IgA1，可能会改变这种情况。
