Demirsoy Esra Terzi, Mehtap Ozgur, Atesoglu Elif Birtas, Tarkun Pinar, Eren Necmi, Gedük Ayfer, Hacihanefioglu Abdullah
Department of Hematology, Kocaeli University School of Medicine, Kocaeli, Turkey.
Department of Hematology, Kocaeli University School of Medicine, Kocaeli, Turkey.
Transfus Apher Sci. 2018 Apr;57(2):222-224. doi: 10.1016/j.transci.2018.02.003. Epub 2018 Feb 9.
Most commonly seen side effects with Tyrosine kinase inhibitors (TKI's) are hematologic toxicities. Besides, with dasatinib autoimmune side effects can be seen. Thrombotic thrombocytopenic purpura (TTP) is a life- threatening disease that can be related to various causes mainly autoimmune disorders or antineoplastic drugs. Few cases of TKI associated secondary thrombotic microangiopathies (TMA) have been reported in literature. Most of cases were diagnosed as hemolytic uremic syndrome (HUS) rather than TTP. Herein, we describe a 37-year-old CML patient who was diagnosed as immune-mediated TTP related to dasatinib.
酪氨酸激酶抑制剂（TKIs）最常见的副作用是血液学毒性。此外，使用达沙替尼时还可见自身免疫性副作用。血栓性血小板减少性紫癜（TTP）是一种危及生命的疾病，可能与多种原因有关，主要是自身免疫性疾病或抗肿瘤药物。文献中报道的与TKI相关的继发性血栓性微血管病（TMA）病例较少。大多数病例被诊断为溶血性尿毒症综合征（HUS）而非TTP。在此，我们描述了一名37岁的慢性粒细胞白血病患者，该患者被诊断为与达沙替尼相关的免疫介导性TTP。
