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接种 Moderna 加强针疫苗后出现血栓性血小板减少性紫癜。

Thrombotic thrombocytopenic purpura following administration of the Moderna booster vaccine.

机构信息

Internal Medicine, Beaumont Health, Royal Oak, Michigan, USA

Internal Medicine, Beaumont Health, Royal Oak, Michigan, USA.

出版信息

BMJ Case Rep. 2022 Mar 24;15(3):e247576. doi: 10.1136/bcr-2021-247576.

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a type of thrombotic microangiopathy that is characterized by microangiopathic haemolytic anaemia, consumption thrombocytopenia and organ injury. It is caused by a severe deficiency of ADAMTS13, which can be either congenital or acquired. There is a plethora of things that can cause the acquired form, including medications and infections. Vaccines have also been shown to cause TTP. In the midst of the COVID-19 pandemic, with multiple new vaccines being developed and distributed to the masses, the medical community needs to be aware of adverse events associated with these new vaccines. We present a case of TTP following administration of the Moderna booster vaccine.

摘要

血栓性血小板减少性紫癜(TTP)是一种血栓性微血管病,其特征为微血管性溶血性贫血、消耗性血小板减少和器官损伤。它由 ADAMTS13 的严重缺乏引起,这种缺乏既可以是先天性的,也可以是后天获得的。有很多因素可以导致后天性 TTP,包括药物和感染。疫苗也已被证明会引起 TTP。在 COVID-19 大流行期间,随着多种新疫苗的开发和向大众分发,医学界需要意识到这些新疫苗相关的不良事件。我们报告了一例接种 Moderna 加强针后发生 TTP 的病例。

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