Internal Medicine, Beaumont Health, Royal Oak, Michigan, USA
Internal Medicine, Beaumont Health, Royal Oak, Michigan, USA.
BMJ Case Rep. 2022 Mar 24;15(3):e247576. doi: 10.1136/bcr-2021-247576.
Thrombotic thrombocytopenic purpura (TTP) is a type of thrombotic microangiopathy that is characterized by microangiopathic haemolytic anaemia, consumption thrombocytopenia and organ injury. It is caused by a severe deficiency of ADAMTS13, which can be either congenital or acquired. There is a plethora of things that can cause the acquired form, including medications and infections. Vaccines have also been shown to cause TTP. In the midst of the COVID-19 pandemic, with multiple new vaccines being developed and distributed to the masses, the medical community needs to be aware of adverse events associated with these new vaccines. We present a case of TTP following administration of the Moderna booster vaccine.
血栓性血小板减少性紫癜(TTP)是一种血栓性微血管病,其特征为微血管性溶血性贫血、消耗性血小板减少和器官损伤。它由 ADAMTS13 的严重缺乏引起,这种缺乏既可以是先天性的,也可以是后天获得的。有很多因素可以导致后天性 TTP,包括药物和感染。疫苗也已被证明会引起 TTP。在 COVID-19 大流行期间,随着多种新疫苗的开发和向大众分发,医学界需要意识到这些新疫苗相关的不良事件。我们报告了一例接种 Moderna 加强针后发生 TTP 的病例。