Fuchs J, Zimmer G
Biochem Pharmacol. 1986 Dec 15;35(24):4381-5. doi: 10.1016/0006-2952(86)90752-5.
Contents of high energy phosphates in the isolated perfused rat heart were followed during ischemia and reperfusion using 31P NMR spectroscopy. Application of 2-mercaptopropionylglycine resulted in significantly higher content of ATP in the reperfusion phase whereas during ischemia no differences between control and therapy hearts were found. Analysis of postischemic mitochondrial function reveals that improved ATP level is paralleled by an increased respiratory control index and a reduced ATPase activity. It is suggested that 2-mercaptopropionylglycine may cause increase of high energy phosphates during reperfusion by improving mitochondrial oxidative phosphorylation.
利用31P核磁共振波谱法，在缺血和再灌注过程中跟踪分离灌注大鼠心脏中的高能磷酸盐含量。应用2-巯基丙酰甘氨酸导致再灌注期ATP含量显著更高，而在缺血期间，对照心脏和治疗心脏之间未发现差异。对缺血后线粒体功能的分析表明，ATP水平的提高与呼吸控制指数的增加和ATP酶活性的降低相平行。有人提出，2-巯基丙酰甘氨酸可能通过改善线粒体氧化磷酸化作用，在再灌注期间导致高能磷酸盐增加。
