Sullivan Adrienne, Bland Ruth M, Hague Rosie
Paediatric Department, Wishaw General Hospital, Wishaw, UK.
General Paediatric Department, Royal Hospital for Children, Glasgow, UK.
Arch Dis Child Educ Pract Ed. 2018 Oct;103(5):231-235. doi: 10.1136/archdischild-2016-312386. Epub 2018 Feb 23.
Low or absent immunoglobulin A (IgA) levels are frequently found in children in whom immunodeficiency is not suspected. IgA deficiency is the most common primary immunodeficiency disorder in the UK affecting approximately 1 in 600 people. Isolated IgA deficiency is often identified coincidentally when investigating a child for conditions such as coeliac disease. The aim of this article is to provide a structured approach to the history, investigation and management of an isolated IgA deficiency.
在未怀疑有免疫缺陷的儿童中，经常发现免疫球蛋白A（IgA）水平较低或缺乏。IgA缺乏是英国最常见的原发性免疫缺陷病，约每600人中就有1人受影响。孤立性IgA缺乏常在对患有乳糜泻等疾病的儿童进行检查时被偶然发现。本文旨在提供一种针对孤立性IgA缺乏的病史、检查及管理的结构化方法。
