雄激素剥夺疗法对日本前列腺癌患者骨密度的影响。
Effect of Androgen-deprivation Therapy on Bone Mineral Density in Japanese Patients with Prostate Cancer.
作者信息
Miyazawa Yoshiyuki, Sekine Yoshitaka, Syuto Takahiro, Nomura Masashi, Koike Hidekazu, Matsui Hiroshi, Shibata Yasuhiro, Ito Kazuto, Suzuki Kazuhiro
机构信息
Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan
Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan.
出版信息
In Vivo. 2018 Mar-Apr;32(2):409-412. doi: 10.21873/invivo.11254.
BACKGROUND/AIM: To evaluate bone mineral density (BMD) in Japanese patients with prostate cancer (PCa) after administering androgen deprivation therapy (ADT) for 2 years.
PATIENTS AND METHODS
A total of 84 Japanese patients with PCa were enrolled in this study during the period 2008-2011. BMD was measured by dual energy X-ray absorptiometry, every 6 months. The fracture risk assessment tool (FRAX) score was calculated before starting ADT. We evaluated the change in BMD over a 2-year period and the relationship between this change, the FRAX score, and the estimated glomerular filtration rate (eGFR).
RESULTS
Compared to baseline, BMD decreased by 2.50% at 6 months after ADT, by 4.28% after 12 months, by 5.34% after 18 months, and by 6.16% after 2 years (all p<0.05). Multivariate analysis revealed that the eGFR, according to a threshold rate of 73.5 ml/min, was a significant factor in BMD.
CONCLUSION
Lumbar BMD in Japanese patients with PCa decreased by 4.28% at 1 year after ADT and by 6.16% after 2 years. We found a correlation between the decrease in BMD and the eGFR before initiating ADT, suggesting a small BMD reduction in patients with PCa who have good renal function.
背景/目的：评估接受2年雄激素剥夺治疗（ADT）的日本前列腺癌（PCa）患者的骨密度（BMD）。
患者与方法
2008年至2011年期间，共有84例日本PCa患者纳入本研究。每6个月采用双能X线吸收法测量BMD。在开始ADT前计算骨折风险评估工具（FRAX）评分。我们评估了2年内BMD的变化以及该变化、FRAX评分和估计肾小球滤过率（eGFR）之间的关系。
结果
与基线相比，ADT后6个月BMD下降2.50%，12个月后下降4.28%，18个月后下降5.34%，2年后下降6.16%（均p<0.05）。多变量分析显示，根据阈值73.5 ml/min的eGFR是BMD的一个重要因素。
结论
日本PCa患者腰椎BMD在ADT后1年下降4.28%，2年后下降6.16%。我们发现BMD下降与开始ADT前的eGFR之间存在相关性，提示肾功能良好的PCa患者BMD降低幅度较小。
Zotero 插件