Otoshi Takehiro, Kataoka Yuki, Kaku Sawako, Iki Reika, Hirabayashi Masataka
Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
In Vivo. 2018 Mar-Apr;32(2):445-450. doi: 10.21873/invivo.11260.
The aim of the present study was to assess the prognostic utility of the pretreatment blood neutrophil-to-lymphocyte ratio (NLR) and the C-reactive protein-to-albumin ratio (CAR) in patients with inoperable malignant pleural mesothelioma (MPM).
The medical records of consecutive patients with histologically confirmed MPM from our hospital between January 2007 and August 2017 were retrospectively reviewed. The primary outcome was overall survival (OS). Univariate and multivariate analyses for the prognostic factors were performed using a Cox proportional hazards model.
A total of 143 patients with inoperable MPM were included. On multivariate analysis, pretreatment CAR was an independent factor associated with worse OS (hazard ratio(HR)=1.72; 95% confidence interval(CI)=1.11-2.67; p=0.016). However, NLR was not associated with OS in any of the analyses.
CAR appears to be a prognostic factor in patients with inoperable MPM.
本研究旨在评估治疗前血液中性粒细胞与淋巴细胞比值（NLR）及C反应蛋白与白蛋白比值（CAR）在无法手术的恶性胸膜间皮瘤（MPM）患者中的预后价值。
回顾性分析2007年1月至2017年8月我院收治的经组织学确诊的MPM连续患者的病历。主要结局为总生存期（OS）。采用Cox比例风险模型对预后因素进行单因素和多因素分析。
共纳入143例无法手术的MPM患者。多因素分析显示，治疗前CAR是与较差OS相关的独立因素（风险比（HR）=1.72；95%置信区间（CI）=1.11-2.67；p=0.016）。然而，在任何分析中NLR均与OS无关。
CAR似乎是无法手术的MPM患者的一个预后因素。
