C反应蛋白与白蛋白比值在接受放化疗后手术的直肠癌患者中的临床意义
Clinical Significance of C-Reactive Protein-to-Albumin Ratio with Rectal Cancer Patient Undergoing Chemoradiotherapy Followed by Surgery.
作者信息
Ide Shozo, Toiyama Yuji, Okugawa Yoshinaga, Oki Satoshi, Yasuda Hiromi, Fujikawa Hiroyuki, Yoshiyama Shigeyuki, Hiro Junitiro, Kobayashi Minako, Ohi Masaki, Araki Toshimitsu, Kusunoki Masato
机构信息
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
出版信息
Anticancer Res. 2017 Oct;37(10):5797-5804. doi: 10.21873/anticanres.12022.
BACKGROUND/AIM: This study was designed to evaluate the clinical significance of the C-reactive protein-to-albumin ratio (CAR) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery.
PATIENTS AND METHODS
This retrospective study evaluated the correlation between CAR and prognosis in 115 patients with locally advanced rectal cancer. We also carried out subgroup analyses limited to patients with low modified Glasgow prognosis score (mGPS) (score 0) or pathological TNM stage I-II [ypN(-)].
RESULTS
CAR exhibited significant relationships with sex, tumor invasion, recurrence, serum carcinoembryonic antigen, and mGPS. Elevated CAR was an independent prognostic factor for overall survival (OS) and disease-free survival (DFS) among all patients. Elevated CAR also predicted poor OS and DFS in patients with pathological TNM stage I-II [ypN(-)] and low mGPS score.
CONCLUSION
CAR is a promising predictor of survival and recurrence in patients with rectal cancer treated by CRT.
背景/目的：本研究旨在评估C反应蛋白与白蛋白比值（CAR）在接受术前放化疗（CRT）后手术的直肠癌患者中的临床意义。
患者与方法
这项回顾性研究评估了115例局部晚期直肠癌患者中CAR与预后的相关性。我们还对低改良格拉斯哥预后评分（mGPS）（评分0）或病理TNM分期I-II [ypN(-)]的患者进行了亚组分析。
结果
CAR与性别、肿瘤浸润、复发、血清癌胚抗原和mGPS显著相关。CAR升高是所有患者总生存期（OS）和无病生存期（DFS）的独立预后因素。CAR升高还预示着病理TNM分期I-II [ypN(-)]和低mGPS评分患者的OS和DFS较差。
结论
CAR是接受CRT治疗的直肠癌患者生存和复发的有前景的预测指标。
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