Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, United States.
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.
Colloids Surf B Biointerfaces. 2018 May 1;165:144-149. doi: 10.1016/j.colsurfb.2018.02.032. Epub 2018 Feb 15.
In this work, we developed a new class of branched polyrotaxane hydrogel made of 4-arm polyethylene glycol (4-PEG) and α-cyclodextrin (α-CD) using supramolecular host-guest interactions as a cross-linking strategy. Because of the dynamic nature of the non-covalent host-guest cross-linking, the resulting supramolecular α-CD/4-PEG hydrogels show thixotropic behavior and undergo a reversible gel-sol transition in response to shear stress change. We loaded the antiglaucoma drug brimonidine into the α-CD/4-PEG gel and found the drug release kinetics was controlled by shear stress. This thixotropic shear thinning property makes the supramolecular hydrogels highly attractive in drug delivery applications and suitable for preparation of injectable drug formulations.
在这项工作中，我们使用超分子主客体相互作用作为交联策略，开发了一种由 4 臂聚乙二醇（4-PEG）和α-环糊精（α-CD）组成的新型支化聚轮烷水凝胶。由于非共价主客体交联的动态性质，所得的超分子α-CD/4-PEG 水凝胶表现出触变行为，并在响应剪切应力变化时发生可逆的凝胶-溶胶转变。我们将抗青光眼药物溴莫尼定载入到 α-CD/4-PEG 凝胶中，并发现药物释放动力学受剪切应力控制。这种触变剪切稀释特性使得超分子水凝胶在药物输送应用中极具吸引力，适合制备可注射药物制剂。
