Shin Gi Ru, Kim Hee Eun, Kim Jae Ho, Choi Sangdun, Kim Moon Suk
Department of Molecular Science and Technology, Ajou University, 206, World Cup-ro, Yeongtong-gu, Suwon-si 16499, Gyeonggi-do, Korea.
Research Institute, Medipolymer, 274-Samsung-ro, Suwon-si 16522, Gyeonggi-do, Korea.
Pharmaceutics. 2021 Nov 18;13(11):1953. doi: 10.3390/pharmaceutics13111953.
Chemotherapy has been linked to a variety of severe side effects, and the bioavailability of current chemotherapeutic agents is generally low, which decreases their effectiveness. Therefore, there is an ongoing effort to develop drug delivery systems to increase the bioavailability of these agents and minimize their side effects. Among these, intratumoral injections using in situ-forming hydrogels can improve drugs' bioavailability and minimize drugs' accumulation in non-target organs or tissues. This review describes different types of injectable in situ-forming hydrogels and their intratumoral injection for cancer treatment, after which we discuss the antitumor effects of intratumoral injection of drug-loaded hydrogels. This review concludes with perspectives on the future applicability of, and challenges for, the adoption of this drug delivery technology.
化疗与多种严重的副作用相关联，并且当前化疗药物的生物利用度普遍较低，这降低了它们的有效性。因此，人们一直在努力开发药物递送系统，以提高这些药物的生物利用度并将其副作用降至最低。其中，使用原位形成水凝胶的瘤内注射可以提高药物的生物利用度，并使药物在非靶器官或组织中的蓄积降至最低。本综述描述了不同类型的可注射原位形成水凝胶及其用于癌症治疗的瘤内注射，之后我们讨论了瘤内注射载药水凝胶的抗肿瘤作用。本综述最后展望了这种药物递送技术的未来适用性和面临的挑战。
