GReD, Université Clermont Auvergne, CNRS, INSERM, Clermont-Ferrand, France.
GReD, Université Clermont Auvergne, CNRS, INSERM, Clermont-Ferrand, France.
Curr Top Dev Biol. 2018;128:81-104. doi: 10.1016/bs.ctdb.2017.12.001. Epub 2018 Feb 2.
At the time of implantation, the mouse blastocyst has developed three cell lineages: the epiblast (Epi), the primitive endoderm (PrE), and the trophectoderm (TE). The PrE and TE are extraembryonic tissues but their interactions with the Epi are critical to sustain embryonic growth, as well as to pattern the embryo. We review here the cellular and molecular events that lead to the production of PrE and Epi lineages and discuss the different hypotheses that are proposed for the induction of these cell types. In the second part, we report the current knowledge about the epithelialization of the PrE.
在着床时，小鼠囊胚已经发育出三个细胞谱系：上胚层（Epi）、原始内胚层（PrE）和滋养外胚层（TE）。PrE 和 TE 是胚胎外组织，但它们与 Epi 的相互作用对于维持胚胎生长以及胚胎模式至关重要。在这里，我们回顾了导致 PrE 和 Epi 谱系产生的细胞和分子事件，并讨论了用于诱导这些细胞类型的不同假说。在第二部分，我们报告了关于 PrE 上皮化的当前知识。
