胆酸的下丘脑感知：一种肠道感觉。
Hypothalamic Sensing of Bile Acids, a Gut Feeling.
机构信息
Diabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
出版信息
Trends Endocrinol Metab. 2018 Jun;29(6):363-366. doi: 10.1016/j.tem.2018.02.001. Epub 2018 Feb 21.
PMID:29477281
Abstract
Bile acids facilitate dietary fat absorption upon release into the small intestine after a meal. A recent study by Liu and colleagues identifies a gut-brain axis wherein bile acids signal an energy-replete state to hypothalamic AgRP neurons via activation of neuronal FGF receptors, which orchestrate whole-body glucose metabolism.
摘要
胆汁酸在餐后被释放到小肠中，促进膳食脂肪吸收。最近，Liu 及其同事的一项研究确定了一个肠-脑轴，其中胆汁酸通过激活神经元 FGF 受体向下丘脑 AgRP 神经元发出能量充足的信号，从而协调全身葡萄糖代谢。
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