FISH 钓取糖皮质激素诱导的染色质重排的新型动态模式。
FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization.
机构信息
University of Bristol, Translational Health Sciences, Dorothy Hodgkin Building, Whitson Street, Bristol BS13NY, UK.
University of Bristol, Translational Health Sciences, Dorothy Hodgkin Building, Whitson Street, Bristol BS13NY, UK.
出版信息
Trends Endocrinol Metab. 2018 Apr;29(4):204-207. doi: 10.1016/j.tem.2018.02.003. Epub 2018 Feb 21.
In a recent study, Jubb et al. used 3D DNA FISH to assess glucocorticoid-induced 'chromatin decompaction' at multiple loci. Determinants of the specificity, speed, and duration of this phenomenon further enhance our understanding of how the glucocorticoid receptor (GR) dynamically alters chromatin accessibility during acute-phase transcriptional regulation and beyond.
在最近的一项研究中，Jubb 等人使用 3D DNA FISH 来评估糖皮质激素诱导的多个基因座上的“染色质松解”。这一现象的特异性、速度和持续时间的决定因素进一步增强了我们对糖皮质激素受体 (GR) 在急性转录调控期间以及之后如何动态改变染色质可及性的理解。
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