Endometrial aspiration studies on Isaacs cell sampler with cytohistologic correlation.

Endometrial aspiration material obtained with the Isaacs cell sampler from 220 patients was studied and correlated with tissue biopsy from 172 of these patients. Of 52 endometrial carcinomas, there were two false-negative readings. In addition, five cases thought to be malignancies by cytologic criteria were not confirmed by histology. Therefore, the endometrial cell sampler showed a specificity of 96.85%, sensitivity of 96.15% and predictive value of 90.90%. Only nine cases of unsatisfactory cellular samples were obtained as compared to 13 cases of insufficient material by dilatation and curettage.