Stárka Luboslav, Hill Martin, Kolatorova Lucie, Dušková Michaela
Institute of Endocrinology, Národní 8, 11694 Prague 1, Czech Republic.
Steroids. 2018 Jun;134:88-95. doi: 10.1016/j.steroids.2018.02.005. Epub 2018 Feb 23.
Androst-5-ene-triols are metabolites of dehydroepiandrosterone, the most abundant steroid hormone in human circulation. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7β-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3β,7β,17β-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on the levels and effects of androst-5-ene-triols in experimental animals and of their the pharmacological perspective, little is known about androst-5-ene-3β,7α/β,17β-triols circulating in human blood, their regulation by the hypothalamo-pituitary-adrenal axis, or their daily concentration variability. Here we provide some data on androst-5-ene-3β,7α/β,17β-triol concentrations under various conditions in men and women.
雄甾-5-烯三醇是脱氢表雄酮的代谢产物，脱氢表雄酮是人体循环中含量最丰富的类固醇激素。在啮齿动物中的许多观察结果表明，7β-羟基-雄甾-5-烯具有抗炎和免疫调节活性，基于这些实验，雄甾-5-烯-3β,7β,17β-三醇被认为是治疗自身免疫性疾病的潜在药物。与关于雄甾-5-烯三醇在实验动物中的水平和作用以及从药理学角度的相当丰富的信息形成对比的是，对于在人体血液中循环的雄甾-5-烯-3β,7α/β,17β-三醇、它们受下丘脑-垂体-肾上腺轴的调节或它们的每日浓度变异性知之甚少。在这里，我们提供了关于男性和女性在各种条件下雄甾-5-烯-3β,7α/β,17β-三醇浓度的一些数据。
