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5α-雄甾烷-3β-17β-二醇的垂体代谢：迅速且大量地转化为5α-雄甾烷-3β,6α,17β-三醇和5α-雄甾烷-3β,7α,17β-三醇。

Pituitary metabolism of 5alpha-androstane-3beta-17beta-diol: intense and rapid conversion into 5alpha-androstane-3beta,6alpha,17beta-triol and 5alpha-androstane-3beta,7alpha, 17beta-triol.

作者信息

Guiraud J M, Morfin R, Ducouret B, Samperez S, Jouan P

出版信息

Steroids. 1979 Sep;34(3):241-8. doi: 10.1016/0039-128x(79)90076-x.

DOI:10.1016/0039-128x(79)90076-x
PMID:494365
Abstract

In the male rat pituitary, 5alpha-androstane-3beta, 17beta-diol (3beta-diol) is extensively metabolized into polar steroids. They were identified as 5alpha-androstane-3beta, 6alpha-17beta-triol (6alpha-triol) and 5alpha-androstane-3beta, 7alpha, 17beta-triol (7alpha-triol). 6-alpha-Triol represents 53% and 7alpha-Triol 28% of the total 3beta-diol metabolites. The remaining percentage is related to 6beta and 7beta isomers. The biological role of triols is still unknown.

摘要

在雄性大鼠垂体中，5α-雄甾烷-3β,17β-二醇（3β-二醇）会广泛代谢为极性甾体。它们被鉴定为5α-雄甾烷-3β,6α-17β-三醇（6α-三醇）和5α-雄甾烷-3β,7α,17β-三醇（7α-三醇）。6α-三醇占3β-二醇总代谢产物的53%，7α-三醇占28%。其余百分比与6β和7β异构体有关。三醇的生物学作用仍然未知。

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[Evidence of 5 alpha-androstane-3 beta, 6 alpha, 17 beta-triol and of 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol in the anterior pituitary of the prepuberal male rate].[青春期前雄性大鼠垂体前叶中5α-雄甾烷-3β,6α,17β-三醇和5α-雄甾烷-3β,7α,17β-三醇的证据]
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