黑质部分各向异性分数变化证实了特发性嗅觉丧失患者的 PD 高危状态。
Substantia nigra fractional anisotropy changes confirm the PD at-risk status of patients with idiopathic smell loss.
机构信息
Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
Institute of Psychology, University of Graz, Graz, Austria; BioTechMed, Graz, Austria.
出版信息
Parkinsonism Relat Disord. 2018 May;50:113-116. doi: 10.1016/j.parkreldis.2018.02.026. Epub 2018 Feb 17.
INTRODUCTION
Individuals with unexplained smell loss constitute an at-risk population for the development of Parkinson's disease (PD). Currently, no specific MRI patterns are known for early PD diagnosis. In this study, we measured the fractional anisotropy (FA) in the substantia nigra (SN) in PD patients, in patients with idiopathic smell loss, and in healthy controls.
METHODS
All subjects underwent extensive olfactory testing and MR imaging data were obtained to explore SN diffusion characteristics. The SN regions were manually identified by two independent raters on the individual imaging data.
RESULTS
FA measurements in the SN revealed significant group differences, with reduced values clearly distinguishing PD patients and patients with idiopathic smell loss from healthy controls.
CONCLUSION
These findings indicate a reduced intrinsic integrity of the SN in PD at-risk subjects and support the risk status of patients with idiopathic smell loss.
简介
原因不明的嗅觉丧失个体构成了帕金森病（PD）发展的高危人群。目前，尚不清楚用于早期 PD 诊断的特定 MRI 模式。在这项研究中，我们测量了帕金森病患者、特发性嗅觉丧失患者和健康对照组的黑质（SN）的分数各向异性（FA）。
方法
所有受试者均接受了广泛的嗅觉测试，并获得了 MR 成像数据，以探索 SN 扩散特征。SN 区域由两名独立的评估员在个体成像数据上手动识别。
结果
SN 中的 FA 测量值显示出显著的组间差异，降低的值清楚地区分了 PD 患者和特发性嗅觉丧失患者与健康对照组。
结论
这些发现表明 PD 高危人群的 SN 内在完整性降低，并支持特发性嗅觉丧失患者的风险状况。
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