钙化防御症一例伴非霍奇金淋巴瘤：病例报告及文献复习。
Calciphylaxis in a Patient With Non-Hodgkin Lymphoma: Case Report and Literature Review.
机构信息
1 Dermatology Department, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
2 Pathology Department, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
出版信息
J Cutan Med Surg. 2018 Sep/Oct;22(5):524-526. doi: 10.1177/1203475418761867. Epub 2018 Feb 24.
BACKGROUND
Calciphylaxis is a well-known entity in end-stage kidney disease and after renal transplant. Cases of nonuremic calciphylaxis (NUC) have also been reported, but data on this rare condition are mainly empirical.
OBJECTIVE
We discuss a case of NUC secondary to spontaneous tumour lysis syndrome in a patient who had chemotherapy for non-Hodgkin lymphoma and present a review of the literature to better characterize malignancy-associated NUC.
METHODS
We identified 12 published cases of malignancy-associated NUC.
RESULTS
This systematic review of malignancy-associated NUC did not show a relationship between the type of malignancy, the distribution of skin lesions, or mortality. However, distal more than proximal involvement seems to be more frequently associated with calcium phosphate imbalance.
CONCLUSION
Clinicians must maintain a high index of suspicion for calciphylaxis when evaluating patients with cutaneous lesions developed in the setting of malignancy.
背景
钙化防御是终末期肾病和肾移植后的一种熟知病症。非尿毒症性钙化防御（NUC）的病例也有报道，但关于这种罕见病症的数据主要是经验性的。
目的
我们讨论了一例继发于非霍奇金淋巴瘤化疗后自发性肿瘤溶解综合征的 NUC 病例，并对文献进行了回顾，以更好地描述与恶性肿瘤相关的 NUC。
方法
我们确定了 12 例与恶性肿瘤相关的 NUC 发表病例。
结果
这项关于与恶性肿瘤相关的 NUC 的系统回顾并没有显示出恶性肿瘤的类型、皮肤损伤的分布或死亡率之间存在关系。然而，远端受累多于近端受累似乎更常与钙磷失衡有关。
结论
当评估在恶性肿瘤背景下出现皮肤损伤的患者时，临床医生必须保持对钙化防御的高度警惕。
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