Department of Laboratory Medicine & Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.
Division of Antimicrobial Resistance, National Institute of Health, Centers for Disease Control & Prevention, Cheongju, South Korea.
Future Microbiol. 2018 Jun 1;13:771-783. doi: 10.2217/fmb-2018-0022. Epub 2018 Feb 26.
To assess the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in South Korea.
MATERIALS & METHODS: From 2011 to 2015, 2487 carbapenem-nonsusceptible Enterobacteriaceae were collected through the Korean National Laboratory Surveillance System. Disk-diffusion for antimicrobial susceptibility, PCR/sequencing to detect carbapenemase genes and multilocus sequence typing for molecular epidemiology were carried out.
The number of carbapenem-nonsusceptible Enterobacteriaceae was increasing approximately 1.5-fold per year and the proportion of CPEs was exponentially confirmed from 2014. KPC was the most dominant, mostly associated with Klebsiella pneumoniae ST11 and ST307, NDM was the second and OXA-48-like was the third dominant carbapenemases. The IMP, VIM and GES-5 CPEs were identified sporadically.
The nation-wide spreads of KPC, NDM and OXA-48-like CPEs were in an alarming epidemiological stage.
评估韩国产碳青霉烯酶肠杆菌科（CPE）的流行病学情况。
2011 年至 2015 年，通过韩国国家实验室监测系统收集了 2487 株对碳青霉烯类药物不敏感的肠杆菌科细菌。进行了药敏纸片扩散法、PCR/测序检测碳青霉烯酶基因和多位点序列分型进行分子流行病学研究。
碳青霉烯类药物不敏感肠杆菌科细菌的数量每年增加约 1.5 倍，2014 年以来 CPE 的比例呈指数级增长。KPC 是最主要的，主要与肺炎克雷伯菌 ST11 和 ST307 相关，NDM 是第二大，OXA-48 样酶是第三大主要碳青霉烯酶。IMP、VIM 和 GES-5 产碳青霉烯酶肠杆菌科细菌则是零星出现。
全国范围内 KPC、NDM 和 OXA-48 样 CPE 的传播处于令人警惕的流行阶段。
