Gardner D G, Deschepper C F, Baxter J D
Hypertension. 1987 Jan;9(1):103-6. doi: 10.1161/01.hyp.9.1.103.
The gene for atrial natriuretic factor is expressed within the adventitial cells of the rat aortic arch. Atrial natriuretic factor transcripts, similar in overall size (1100-1200 nucleotides) and 5'-termini to those found in the atria, were identified in the arch. Much lower levels (approximately 10-20%) of these transcripts were present in distal thoracic aorta. Atrial natriuretic factor peptide was localized by immunocytochemistry to the adventitia of the arch in regions thought to harbor the aortic baroreceptors. These data suggest a previously unsuspected role for the peptide in regulating systemic blood pressure through the baroreceptor reflex.
心房利钠因子基因在大鼠主动脉弓的外膜细胞中表达。在主动脉弓中鉴定出了心房利钠因子转录本，其总体大小（1100 - 1200个核苷酸）和5'末端与心房中发现的转录本相似。在胸主动脉远端，这些转录本的水平要低得多（约为10 - 20%）。通过免疫细胞化学方法，在被认为含有主动脉压力感受器的区域，心房利钠因子肽定位于主动脉弓的外膜。这些数据表明该肽在通过压力感受器反射调节全身血压方面具有先前未被怀疑的作用。
