Radetti G, Drei F, Betterle C, Mengarda G
Helv Paediatr Acta. 1986 Oct;41(4):377-80.
We describe a child with Down's syndrome who developed an insulin-dependent diabetes mellitus at the age of 8 years and hypothyroidism at the age of 17 years. Because of the well known tendency to autoimmune diseases of patients with Down's syndrome, an autoantibody screening was undertaken. Only a low titre for gastric parietal cell antibodies was repeatedly found, but a gastric biopsy did not reveal chronic atrophic gastritis. Thyroid function should be checked periodically in patients with Down's syndrome since they might suffer from hypothyroidism which may not be recognized for a long time because of its latent onset.
我们描述了一名唐氏综合征患儿，其在8岁时患胰岛素依赖型糖尿病，17岁时患甲状腺功能减退症。由于唐氏综合征患者患自身免疫性疾病的倾向众所周知，因此进行了自身抗体筛查。仅反复发现胃壁细胞抗体滴度较低，但胃活检未发现慢性萎缩性胃炎。唐氏综合征患者应定期检查甲状腺功能，因为他们可能患有甲状腺功能减退症，由于其发病隐匿，可能很长时间都未被发现。
