Hunter S, Kooistra C
J Clin Neuroophthalmol. 1986 Dec;6(4):236-41.
The neuropathologic findings in an idiopathic case of the opsoclonus/myoclonus syndrome are reported. Although neurologic dysfunction may have been more widespread, structural lesions were limited to the cerebellum and inferior olives. Severe depletion of Purkinje cells with preservation of granular cells was evident throughout the neo- and paleocerebellum; however, groups of Purkinje cells were preserved in the archicerebellum. No abnormalities were evident in the paramedian pontine reticular formation of the caudal pons. Inflammation and evidence of anoxic damage were absent. These changes are very similar to those described in paraneoplastic cerebellar cortical degeneration.
报告了1例特发性眼阵挛/肌阵挛综合征的神经病理学发现。尽管神经功能障碍可能更为广泛，但结构损伤仅限于小脑和下橄榄核。在新小脑和旧小脑中，浦肯野细胞严重缺失而颗粒细胞得以保留；然而，原小脑中有成群的浦肯野细胞保留。脑桥尾端的脑桥旁正中网状结构未见明显异常。无炎症及缺氧损伤证据。这些变化与副肿瘤性小脑皮质变性中所描述的变化非常相似。
