The opsoclonus-myoclonus syndrome. A review of the literature.

There have been many reports in the literature of an association of the opsoclonus-myoclonus syndrome and occult neuroblastoma in children. This syndrome is of interest due to the fact that it appears to be a neurological manifestation of an occult carcinoma (without a metastasis to the CNS). This paper examines pathologic, diagnostic, and etiologic issues concerning this syndrome as well as discussing the functional implications of cerebellar lesions associated with it and how those lesions may produce the symptoms observed.