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既往胸骨切开术作为微创二尖瓣手术的一个危险因素。

Previous Sternotomy as a Risk Factor in Minimally Invasive Mitral Valve Surgery.

作者信息

Minol Jan-Philipp, Akhyari Payam, Boeken Udo, Albert Alexander, Rellecke Philipp, Dimitrova Vanessa, Sixt Stephan Urs, Kamiya Hiroyuki, Lichtenberg Artur

机构信息

Department of Cardiovascular Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.

Department of Anaesthesiology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.

出版信息

Front Surg. 2018 Feb 9;5:5. doi: 10.3389/fsurg.2018.00005. eCollection 2018.

Abstract

BACKGROUND

Cardiac redo surgery, especially after a full sternotomy, is considered a high-risk procedure. Minimally invasive mitral valve surgery (MIMVS) is a potential therapeutic approach. However, current developments in interventional cardiology necessitate additional discussion regarding the therapy of choice in high-risk patients. In this context, it is necessary to clarify the perioperative and postoperative risks induced by the factor in the setting of MIMVS. Thus, we present a comparative study analyzing the outcome of MIMVS after previous sternotomy vs. primary operation.

METHODS

We identified 19 patients who received isolated or combined mitral valve (MV) surgery the MIMVS approach after previous full sternotomy (PS group) and compared the results to those of a group of 357 patients who received primary MIMVS (non-PS group). After a propensity score analysis, groups of  = 15 and  = 131, respectively, were subjected to a comparative evaluation. A 1-year follow-up analysis of functional cardiac parameters and clinical symptoms was performed, accompanied by a Kaplan-Meier analysis.

RESULTS

Except for the rate of realized MV reconstructions (PS group: 53.8% vs. non-PS group: 85.5%;  = 0.011), no significant differences were to be noted within the intraoperative and early postoperative course. However, patients in the PS group experienced an increased intensive care unit stay length (PS group: 2 days, 95% CI, 1-8 vs. non-PS group: 1 day, 95% CI, 1-2;  = 0.072). The follow-up examinations revealed excellent functional and clinical outcomes for both groups. The Kaplan-Meier analysis displayed no significant difference regarding the postoperative mortality ( = 0.929) related to the patients at risk.

CONCLUSION

A previous sternotomy remains a risk factor for MIMVS and demands special attention in the early postoperative period. Nevertheless, the early- and late-term results concerning the functional and clinical outcomes suggest that the MIMVS procedure is satisfactory, even after a full sternotomy.

摘要

背景

心脏再次手术,尤其是在正中开胸术后进行的手术,被认为是一种高风险手术。微创二尖瓣手术(MIMVS)是一种潜在的治疗方法。然而,介入心脏病学的当前发展使得有必要就高危患者的首选治疗方法进行进一步讨论。在此背景下,有必要阐明在MIMVS情况下该因素所导致的围手术期和术后风险。因此,我们开展了一项比较研究,分析既往开胸术后MIMVS与初次手术的结果。

方法

我们确定了19例接受孤立或联合二尖瓣(MV)手术且采用MIMVS方法的患者,这些患者既往接受过正中开胸(PS组),并将结果与一组357例接受初次MIMVS的患者(非PS组)进行比较。经过倾向评分分析后,分别对每组n = 15和n = 131的患者进行比较评估。对心脏功能参数和临床症状进行了为期1年的随访分析,并进行了Kaplan-Meier分析。

结果

除了成功进行MV重建的比例(PS组:53.8% 对非PS组:85.5%;P = 0.011)外,在术中和术后早期过程中未发现显著差异。然而,PS组患者的重症监护病房住院时间延长(PS组:2天,95% CI,1 - 8天 对非PS组:1天,95% CI,1 - 2天;P = 0.072)。随访检查显示两组的功能和临床结果均良好。Kaplan-Meier分析显示,与有风险的患者相关的术后死亡率无显著差异(P = 0.929)。

结论

既往开胸手术仍然是MIMVS的一个风险因素,在术后早期需要特别关注。尽管如此,关于功能和临床结果的早期和晚期结果表明,即使在正中开胸术后,MIMVS手术也是令人满意的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d4/5811546/eeabc108e55d/fsurg-05-00005-g001.jpg

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