Ohsawa M, Asai M, Masahashi T, Narita O, Tomoda Y, Matsui N
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Nov;38(11):2081-8.
To clarify the mechanism of hyperandrogenic anovulation, the binding capacity of sex-hormone-binding globulin (SHBG-BC), the levels of free steroid hormones, and the levels of basal serum testosterone (T), estradiol (E2), estrone (E1) and gonadotropins were determined in 42 hyperandrogenic anovulatory women. The mean levels of basal T (0.74 +/- 0.04 ng/ml, p less than 0.001), free T (3.07 +/- 0.51 ng/dl, p less than 0.01) and free E2 (2.26 +/- 0.27 pg/ml, p less than 0.05), basal luteinizing hormone (LH) (33.4 +/- 2.7 mIU/ml, p less than 0.001), responsiveness of LH (180.7 +/- 21.5 mIU/ml, p less than 0.001) after luteinizing hormone releasing hormone (LHRH) administration, and the basal LH/basal follicle stimulating hormone (FSH) ratio (3.42 +/- 0.25, p less than 0.001) in the patients were significantly higher, the SHBG-BC level (1.76 +/- 0.33 micrograms DHT bound/dl, p less than 0.05) significantly reduced, and basal levels of E2 (38.0 +/- 3.2 pg/ml) and E1 (110 +/- 13 pg/ml) unchanged compared to the controls. These findings suggest that increased T in hyperandrogenic anovulatory women results in decreased SHBG-BC and increased free T and E2 which might be the cause of inappropriate gonadotropin secretion followed by chronic anovulation.
为阐明高雄激素性无排卵的机制，对42例高雄激素性无排卵女性测定了性激素结合球蛋白结合能力（SHBG-BC）、游离类固醇激素水平以及基础血清睾酮（T）、雌二醇（E2）、雌酮（E1）和促性腺激素水平。与对照组相比，患者的基础T平均水平（0.74±0.04 ng/ml，p<0.001）、游离T（3.07±0.51 ng/dl，p<0.01）和游离E2（2.26±0.27 pg/ml，p<0.05）、基础促黄体生成素（LH）（33.4±2.7 mIU/ml，p<0.001）、注射促黄体生成素释放激素（LHRH）后LH反应性（180.7±21.5 mIU/ml，p<0.001）以及基础LH/基础促卵泡生成素（FSH）比值（3.42±0.25，p<0.001）显著升高，SHBG-BC水平（1.76±0.33微克双氢睾酮结合/dl，p<0.05）显著降低，E2（38.0±3.2 pg/ml）和E1（110±13 pg/ml）基础水平无变化。这些发现提示，高雄激素性无排卵女性T升高导致SHBG-BC降低、游离T和E2升高，这可能是促性腺激素分泌异常继而导致慢性无排卵的原因。
