Angel C Y, Bruneval P, Camilleri J P, Raynaud A, Pernes J M, Gaux J C
J Radiol. 1986 Aug-Sep;67(8-9):647-51.
Histopathologic changes were evaluated after arterial dilatation in a group of 8 rabbits. Rabbits were given an atherogenic diet and then aortic disendothelialization performed using a Fogarthy catheter. This was followed three to five months later by percutaneous angioplasty using a balloon catheter. Animals were sacrificed and histology of arterial segments determined. Findings showed thickening of intima with lipophagic infiltration. In contrast, the media was greatly altered with rupture of internal elastic fibers and a true cleavage plane suggestive of subadventitial dissection: the adventia was not modified.
在一组8只兔子中评估了动脉扩张后的组织病理学变化。给兔子喂食致动脉粥样化饮食,然后使用Fogarty导管进行主动脉去内皮化。三到五个月后,使用球囊导管进行经皮血管成形术。处死动物并确定动脉段的组织学情况。结果显示内膜增厚并伴有噬脂细胞浸润。相比之下,中膜发生了显著改变,内部弹性纤维断裂,出现了提示外膜下剥离的真正分离平面:外膜未发生改变。