Zollikofer C L, Chain J, Salomonowitz E, Runge W, Bruehlmann W F, Castaneda-Zuniga W R, Amplatz K
Radiology. 1984 May;151(2):355-63. doi: 10.1148/radiology.151.2.6231654.
Histological changes which developed after percutaneous transluminal angioplasty in normal and atherosclerotic rabbit aortas were correlated with balloon size and inflation time. In normal rabbits, progressive changes were observed in the intima and media with increasing balloon size and inflation time. The atherosclerotic aortas exhibited unpredictable fragility, with limited correlation between histological changes, balloon size, and inflation time, attributable mainly to the distribution and thickness of plaques. In atherosclerotic vessels, the mechanism of angioplasty consisted of plaque dehiscence and fracture, followed by overstretching of the plaque-free wall segments. No plaque compression was observed.
正常和动脉粥样硬化兔主动脉经皮腔内血管成形术后发生的组织学变化与球囊大小和充盈时间相关。在正常兔中，随着球囊大小和充盈时间增加，内膜和中膜出现渐进性变化。动脉粥样硬化主动脉表现出不可预测的脆性，组织学变化、球囊大小和充盈时间之间的相关性有限，这主要归因于斑块的分布和厚度。在动脉粥样硬化血管中，血管成形术的机制包括斑块裂开和断裂，随后无斑块壁段过度伸展。未观察到斑块受压。
