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年轻和老年大鼠骨骼肌中三（羟甲基）氨基甲烷对钙镁 - ATP酶活性激活作用的差异。

Difference in activation by Tris(hydroxymethyl)aminomethane of Ca,Mg-ATPase activity between young and old rat skeletal muscles.

作者信息

Nakano M, Tauchi H

出版信息

Mech Ageing Dev. 1986 Nov 14;36(3):287-94. doi: 10.1016/0047-6374(86)90094-1.

DOI:10.1016/0047-6374(86)90094-1
PMID:2948083
Abstract

Fresh weight of rat skeletal muscles (M. tibialis anterior) was decreased with age. Specific activity of myosin-ATPase in the homogenate was decreased significantly at later stages of age, but not Ca,Mg-ATPase activity. The activity of Ca,Mg-ATPase was activated by high concentration (more than 75 mM) of Tris(hydroxymethyl)aminomethane. The degree of the activation was observed to be an age-related change; the activation of Ca,Mg-ATPase activity in old rats was lower than that of young rats.

摘要

大鼠骨骼肌（胫前肌）的鲜重随年龄增长而降低。匀浆中肌球蛋白 - ATP酶的比活性在年龄较大阶段显著降低，但钙、镁 - ATP酶活性未降低。钙、镁 - ATP酶的活性可被高浓度（超过75 mM）的三（羟甲基）氨基甲烷激活。观察到激活程度存在与年龄相关的变化；老年大鼠中钙、镁 - ATP酶活性的激活低于年轻大鼠。

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