Nakano M, Baba H, Tauchi H, Sato T
Mech Ageing Dev. 1985 Jul-Aug;31(2):187-95. doi: 10.1016/s0047-6374(85)80029-4.
Age related change of the human minor pectoral muscles was biochemically demonstrated. Myosin-ATPase activity was significantly decreased with age, and was activated with Tris. The degree of the activation by Tris was observed to be lower in old aged patients than in the young. Furthermore, at low concentration of CaCl2 (less than 100 microM), myosin-ATPase activity was higher in the young age than in the old, while at high concentration of CaCl2 (more than 1 mM) no significant difference was observed between young and old age. Decrease with age in activation by primary amine such as Tris would play an important role in the muscle working capacity in old age.
已通过生物化学方法证明了人类胸小肌与年龄相关的变化。肌球蛋白 - ATP酶活性随年龄显著降低，并且可被Tris激活。观察到老年患者中Tris的激活程度低于年轻人。此外，在低浓度CaCl2（小于100微摩尔）时，年轻人的肌球蛋白 - ATP酶活性高于老年人，而在高浓度CaCl2（大于1毫摩尔）时，年轻人和老年人之间未观察到显著差异。像Tris这样的伯胺激活作用随年龄的降低在老年人的肌肉工作能力中起重要作用。
