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中国汉族人群中血小板反应蛋白-2基因多态性与椎间盘退变的关联分析

Association analysis between thrombospondin-2 gene polymorphisms and intervertebral disc degeneration in a Chinese Han population.

作者信息

Yuan Baisheng, Ji Wei, Fan Bing, Zhang Binglei, Zhao Yulin, Li Jianmin

机构信息

Department of Orthopaedics Health Examination Center, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong Province, P.R. China.

出版信息

Medicine (Baltimore). 2018 Jan;97(2):e9586. doi: 10.1097/MD.0000000000009586.

DOI:10.1097/MD.0000000000009586
PMID:29480856
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5943876/
Abstract

The aim of this study is to determine the contribution of 2 single nucleotide polymorphisms (SNPs) in thrombospondin 2 (THBS2) gene to the development of intervertebral disc degeneration (IDD) in a Chinese Han population.We studied 138 patients with radiographically proven IDD and 136 healthy volunteers with no history of back problems. Magnetic resonance images (MRIs) were obtained for all the patients and controls. Image evaluation for IDD was performed to evaluate the severity of IDD. All patients and controls were genotyped for rs6422747 and rs6422748. Associations between genotypes and development of IDD were analyzed.We found that 2 SNPs in the intron region of THBS2 gene (rs6422747 and rs6422748) were associated with susceptibility of IDD. However, they were not related with severity of IDD, including the total number of degenerative disc and level of IDD. G allele in both SNPs was associated with a higher risk of IDD.The 2 SNPs (rs6422747 and rs6422748) in the THBS2 gene were associated with susceptibility of IDD but not severity of IDD in a Chinese Han population. Our results indicated that THBS2 gene polymorphisms might be the risk factors for IDD. More studies with larger sample size need to be perfected to make sure the functions of THBS2 gene polymorphisms in IDD development.

摘要

本研究旨在确定血小板反应蛋白2（THBS2）基因中的2个单核苷酸多态性（SNP）对中国汉族人群椎间盘退变（IDD）发生发展的影响。我们研究了138例经影像学证实患有IDD的患者和136名无背部问题病史的健康志愿者。对所有患者和对照组均进行了磁共振成像（MRI）检查。对IDD进行图像评估以评估其严重程度。对所有患者和对照组进行rs6422747和rs6422748基因分型。分析基因型与IDD发生发展之间的关联。我们发现THBS2基因内含子区域的2个SNP（rs6422747和rs6422748）与IDD易感性相关。然而，它们与IDD的严重程度无关，包括退变椎间盘总数和IDD程度。两个SNP中的G等位基因均与IDD的较高风险相关。THBS2基因中的2个SNP（rs6422747和rs6422748）与中国汉族人群IDD的易感性相关，但与IDD的严重程度无关。我们的结果表明，THBS2基因多态性可能是IDD的危险因素。需要开展更多样本量更大的研究来完善，以确定THBS2基因多态性在IDD发生发展中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b85/5943876/3fdea8199d5b/medi-97-e9586-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b85/5943876/b67e162df0d5/medi-97-e9586-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b85/5943876/3fdea8199d5b/medi-97-e9586-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b85/5943876/b67e162df0d5/medi-97-e9586-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b85/5943876/3fdea8199d5b/medi-97-e9586-g002.jpg

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本文引用的文献

1
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Front Surg. 2016 Nov 21;3:59. doi: 10.3389/fsurg.2016.00059. eCollection 2016.
2
Association of collagen I, IX and vitamin D receptor gene polymorphisms with radiological severity of intervertebral disc degeneration in Southern European Ancestor.I型胶原、IX型胶原和维生素D受体基因多态性与南欧祖先椎间盘退变影像学严重程度的关联
Eur Spine J. 2015 Nov;24(11):2432-41. doi: 10.1007/s00586-015-4206-5. Epub 2015 Sep 5.
3
The role of matrix metalloproteinase 14 polymorphisms in susceptibility to intervertebral disc degeneration in the Chinese Han population.
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Int J Mol Sci. 2021 Sep 27;22(19):10408. doi: 10.3390/ijms221910408.
4
Genetic Predictors of Early-Onset Spinal Intervertebral Disc Degeneration: Part Two of Two.早发性脊柱椎间盘退变的遗传预测因素：第二篇（共两篇）。
Cureus. 2021 May 22;13(5):e15183. doi: 10.7759/cureus.15183.
5
Integrating multiple microarray dataset analysis and machine learning methods to reveal the key genes and regulatory mechanisms underlying human intervertebral disc degeneration.整合多个微阵列数据集分析和机器学习方法以揭示人类椎间盘退变潜在的关键基因和调控机制。
PeerJ. 2020 Oct 13;8:e10120. doi: 10.7717/peerj.10120. eCollection 2020.
6
Analysis of key genes and pathways associated with the pathogenesis of intervertebral disc degeneration.分析与椎间盘退行性病变发病机制相关的关键基因和通路。
J Orthop Surg Res. 2020 Sep 1;15(1):371. doi: 10.1186/s13018-020-01902-4.
7
Intervertebral Disc Biology: Genetic Basis of Disc Degeneration.椎间盘生物学：椎间盘退变的遗传基础
Curr Mol Biol Rep. 2018;4(4):143-150. doi: 10.1007/s40610-018-0101-2. Epub 2018 Aug 3.
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9
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Neurol Neurochir Pol. 2014 Jan-Feb;48(1):60-2. doi: 10.1016/j.pjnns.2013.04.001. Epub 2014 Jan 23.
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